NCT04906525CompletedNot Applicable
Effects of 6-week Resistance Training Intervention on Gut Microbiome and Cardiometabolic Outcomes in Adults With Overweight and Obesity
University of Missouri-Columbia2 sites in 1 country34 target enrollmentStarted: May 19, 2021Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 34
- Locations
- 2
- Primary Endpoint
- Change in stool microbiome composition
Study Overview
Brief Summary
The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.
Detailed Description
The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age 18-35 years
- •BMI: 25-45 kg/m2
- •Sedentary lifestyle
- •Consistent diet patterns
- •Weight-stable (<4 kg change over the last 3 mo)
- •Willingness to adhere to resistance training protocol and not change diet
- •Non-smoker >1 year or more
Exclusion Criteria
- •Disabilities preventing adherence to resistance training protocol
- •Recent start of medications that affect metabolism or appetite
- •Antibiotics
- •Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
- •Uncontrolled hypertension and blood pressure ≥ 180/110
- •Gastrointestinal disease and/or bariatric surgery
- •Illicit drug use
- •Pregnant or lactating individuals
Outcomes
Primary Outcomes
Change in stool microbiome composition
Time Frame: Change over 6 weeks
16s rRNA sequencing
Change in stool microbiome diversity
Time Frame: Change over 6 weeks
16s rRNA sequencing
Secondary Outcomes
- Sleep Duration(change over 6 weeks)
- Fat mass(Change over 6 weeks)
- Sleep Quality(change over 6 weeks)
- 24hr appetite ratings(Once at baseline and at the end of 6 week intervention)
- Change in Body mass(change over 6 weeks)
- Hip circumference(change over 6 weeks)
- Physical activity(change over 6 weeks)
- Change in blood pressure(change over 6 weeks)
- Fat free mass(Change over 6 weeks)
- Change in glucose regulation(change over 6 weeks)
- Change in fasting glucose(change over 6 weeks)
- Waist circumference(change over 6 weeks)
- Short chain fatty acids(Change over 6 weeks)
Investigators
Jaapna Dhillon
Assistant Professor
University of Missouri-Columbia
Study Sites (2)
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