NCT04906525
Completed
Not Applicable
Effects of 6-week Resistance Training Intervention on Gut Microbiome and Cardiometabolic Outcomes in Adults With Overweight and Obesity
ConditionsExercise Intervention
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Exercise Intervention
- Sponsor
- University of Missouri-Columbia
- Enrollment
- 34
- Locations
- 1
- Primary Endpoint
- Change in stool microbiome composition
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.
Detailed Description
The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.
Investigators
Jaapna Dhillon
Assistant Professor
University of Missouri-Columbia
Eligibility Criteria
Inclusion Criteria
- •Age 18-35 years
- •BMI: 25-45 kg/m2
- •Sedentary lifestyle
- •Consistent diet patterns
- •Weight-stable (\<4 kg change over the last 3 mo)
- •Willingness to adhere to resistance training protocol and not change diet
- •Non-smoker \>1 year or more
Exclusion Criteria
- •Disabilities preventing adherence to resistance training protocol
- •Recent start of medications that affect metabolism or appetite
- •Antibiotics
- •Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
- •Uncontrolled hypertension and blood pressure ≥ 180/110
- •Gastrointestinal disease and/or bariatric surgery
- •Illicit drug use
- •Pregnant or lactating individuals
Outcomes
Primary Outcomes
Change in stool microbiome composition
Time Frame: Change over 6 weeks
16s rRNA sequencing
Change in stool microbiome diversity
Time Frame: Change over 6 weeks
16s rRNA sequencing
Secondary Outcomes
- Sleep Duration(change over 6 weeks)
- Fat mass(Change over 6 weeks)
- Sleep Quality(change over 6 weeks)
- 24hr appetite ratings(Once at baseline and at the end of 6 week intervention)
- Change in Body mass(change over 6 weeks)
- Hip circumference(change over 6 weeks)
- Physical activity(change over 6 weeks)
- Change in blood pressure(change over 6 weeks)
- Fat free mass(Change over 6 weeks)
- Change in glucose regulation(change over 6 weeks)
- Change in fasting glucose(change over 6 weeks)
- Waist circumference(change over 6 weeks)
- Short chain fatty acids(Change over 6 weeks)
Study Sites (1)
Loading locations...
Similar Trials
Recruiting
Not Applicable
The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCIMild Cognitive ImpairmentOlder Adults at High Risk for MCINCT06252844Lithuanian Sports University80
Completed
Not Applicable
Reduction of Cancer Related Fatigue in Patients During TKI TherapyAll Tumor Entities Treated With TKI TherapyNCT01645150German Cancer Research Center20
Recruiting
Not Applicable
Effect of strength training on intestinal environmentormal subjectsJPRN-UMIN000041715Yamagata Prefectural Yonezawa University of Nutrition Sciences20
Recruiting
Not Applicable
Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive WomenArterial HypertensionPostmenopausal; MenorrhagiaCardiovascular DiseasesNCT06538454University of Sao Paulo24
Terminated
Not Applicable
Effects of Functional Exercise on Fitness and QoL in Cancer SurvivorsColorectal CancerNCT02889276University of Portsmouth4