The study of bone cells specifically in osteoarthritis and factors affecting progressio
Completed
- Conditions
- Osteoarthritis of the knee and its progression.Musculoskeletal Diseases
- Registration Number
- ISRCTN12207865
- Lead Sponsor
- Calvary Wakefield Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Diagnosis of OA KL Grade 4
2. Primary knee arthroplasty scheduled.
Exclusion Criteria
1. Rheumatoid arthritis
2. Previous joint surgery for OA
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Whether another joint required replacement due to OA 12 months after surgery. Number of days recorded between surgeries if < 12months<br>2. Are serum sclerostin or synovial sclerostin levels higher in those with progressive OA defined by additional surgery < 12 months from initial surgery. High sclerostin levels in serum and synovial fluid indicate a progressive form of OA
- Secondary Outcome Measures
Name Time Method To identify if any other factors such as Vit D levels and obesity contribute to variable sclerostin levels.<br><br>Vitamin D levels evaluated pre surgery and 12month postoperatively.