Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work

Active, not recruiting

• Conditions: Coronary Artery Disease; Noninvasive Myocardial Work
• Interventions: Diagnostic Test: Transthoracic echocardiography

• Registration Number: NCT05874752
• Lead Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Brief Summary

Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) myocardial function in symptomatic patients with coronary artery disease using the promising method.

Methods: Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography. Images were stored and imported into the software for further offline analysis of PSL-based MW. MW analysis were carried out on each patient for global and regional myocardial function assessment.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-01
• Status Verified: 2023-04
• Study First Submitted: 2023-05-16
• Study First Submitted QC: 2023-05-24
• Last Update Submitted: 2023-05-24
• Study First Posted: 2023-05-25
• Last Update Posted: 2023-05-25
• Primary Completion: 2023-06-01
• Study Completion: 2023-06-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Patients who were hospitalized for coronary angiography with angina or equivalent symptoms.

Exclusion Criteria

Acute coronary syndrome, left main stem coronary disease, left ventricular ejection fraction (LVEF) below 55%, observed resting regional wall motion abnormalities (RWMAs), non-sinus rhythm, intraventricular block, previous cardiac surgery, severe valvular heart disease, hypertrophic cardiomyopathy, myocarditis, pericardial diseases, pulmonary hypertension, and poor image quality.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
nonsignificant coronary artery stenosis group	Transthoracic echocardiography	Exclusion criteria: ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography
significant coronary artery stenosis group	Transthoracic echocardiography	Defined as ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography

Primary Outcome Measures

Name	Time	Method
myocardial function	baseline (before coronary angiography)	noninvasive myocardial work indices

Trial Locations

Locations (1)

Sun Yat-sen Memorial Hospital; 🇨🇳 Guangzhou, Guangdong, China