A Randomised Controlled Clinical Trial of Memory Specificity Training (MEST) for Depression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change from baseline in depressive symptoms on the Beck Depression Inventory II (BDI-II)
研究概览
简要总结
Depression involves the tendency to recall overgeneral personal memories, a phenomenon which has been linked to numerous adverse psychological outcomes. The purpose of this study is to investigate whether a group-based Memory Specificity Training (MEST) programme improves outcomes in depression, and how this compares to an education and support control group. The primary aim is to examine whether MEST, which involves repeated practice retrieving specific autobiographical memories reduces depressive symptoms immediately post-treatment, and whether this is maintained 3 months after treatment. The secondary objective of this trial is to examine the role of hypothesised cognitive processes (ie., rumination, executive control, cognitive avoidance) which may underlie improvements in depression and memory.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Principal diagnosis of Major Depressive Disorder
- •History of more than one previous depressive episode
- •Current diagnosis of a Major Depressive Episode
- •Depressive symptoms rated in the mild-severe range (> 13 on the BDI-II)
- •Memory specificity < .70 (as assessed on the AMT)
排除标准
- •Head trauma
- •Organic brain damage
- •Secondary diagnosis of another affective disorder
- •Psychosis
- •Current drug or alcohol abuse or dependence
- •A diagnosed Axis II disorder
研究组 & 干预措施
Memory Specificity Training
Five weekly one-hour sessions of memory specificity training administered in groups of 5-8 participants.
干预措施: Memory Specificity Training (Behavioral)
Education and Support
Five weekly one-hour sessions of an education-and-discussion supportive intervention, administered in groups of 5-8 participants.
干预措施: Education and Support (Behavioral)
结局指标
主要结局
Change from baseline in depressive symptoms on the Beck Depression Inventory II (BDI-II)
时间窗: Change from baseline to 3 months post-treatment
Symptom severity score
次要结局
- Change in depressive status according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders - IV (SCID-IV)(Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment, and 6-months post-treatment (6-month follow-up for MEST group only))
- Change from baseline in autobiographical memory specificity on Autobiographical Memory Test (AMT)(Change from baseline at end of treatment (approximately 6 weeks) and 3 months post-treatment)
- Change from baseline in depressive symptoms as measured on the BDI-II(Change from baseline to post-treatment (approximately 6-weeks))
- Depression free days following treatment according to the Longitudinal Follow-up Evaluation on the SCID-IV(Post-treatment and 3-month and 6-month follow-up)
研究者
Professor Tim Dalgleish
Professor
Medical Research Council