Effect of Consuming Products Containing Rare Sugars Alongside Sucrose on Glycaemic Response in Healthy Adults
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Integrated area under the curve (iAUC) for plasma glucose.
研究概览
简要总结
Food manufacturers are being tasked to reduce the added sugar content of products. Rare, but natural sugars, may serve as useful sweeteners as they are low-calorie, safe, sweet and have a mild taste. Previous studies have shown that consuming rare sugars alongside other carbohydrates leads to a lower spike in blood glucose after eating. This means that products containing rare sugars may provide health benefits. However, most studies use rare sugars in a glucose drink, so the effect of consuming rare sugars in foods is not known.
The aim of this study is to find out whether consuming sweet crème products containing rare sugars reduces the blood glucose response compared to sucrose-only products. The effect of the rare sugar products on hunger and appetite will also be assessed.
Participants will attend the Clinical Research Facility on 6 occasions, after fasting for 10 hours. At each visit, they will consume a different sample of sweet crème. They will be asked to give blood samples before eating the sample, and at regular intervals for 2 hours afterwards. They will also complete questionnaires to assess their appetite using linear scales. Blood samples will be analysed in the laboratory to measure the level of glucose and insulin at each time point. The changes in blood glucose and insulin after consuming the different samples will be compared to find out if the samples containing rare sugars reduced the response.
详细描述
Main Hypotheses:
This study is designed to test two main hypotheses:
- Sweet crème products containing the rare sugars arabinose or tagatose will cause a lower spike in blood glucose and insulin than sucrose-only products.
- Sweet crème products containing the rare sugars arabinose or tagatose will be no less satiating than sucrose-only products.
The null hypotheses are therefore:
- Levels of blood glucose and insulin are not significantly different after consuming sweet crème products containing rare sugars compared to sucrose-only products.
- Appetite and food intake are significantly higher after consuming sweet crème products containing rare sugars compared to sucrose-only products.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults of any gender and any sociodemographic background, who are capable of giving informed consent.
- •Aged 18 years or over (no upper age limit).
- •Able to understand spoken and written English well enough to understand the consent forms and information sheets, and to give responses to questionnaires.
排除标准
- •Diagnosed hyperglycaemia, insulin resistance, diabetes or high blood pressure.
- •Allergy, intolerance, sensitivity or dietary restriction that would prevent the consumption of the sweet crème samples.
- •Anxiety/phobias that would prevent the sampling of venous blood.
结局指标
主要结局
Integrated area under the curve (iAUC) for plasma glucose.
时间窗: 120 minutes
Differences in the iAUC for plasma glucose after consuming each product.
次要结局
- Integrated area under the curve (iAUC) and peak value for plasma GIP.(120 minutes.)
- Food intake at ad libitum buffet meal(60 minutes)
- 24 hour food intake(24 hours)
- Peak plasma glucose(120 minutes)
- Integrated area under the curve (iAUC) for plasma insulin.(120 minutes.)
- Peak plasma insulin(120 minutes.)
- Integrated area under the curve (iAUC) and peak value for plasma GLP-1.(120 minutes.)