Postoperative Complications in Patients With Obesity Hypoventilation Syndrome Based on Base Excess- OHBE Study: A National, Multicenter, Observational Cohort Study
试验速览
- 阶段
- 不适用
- 入组人数
- 999
- 试验地点
- 1
- 主要终点
- Postoperative complications
研究概览
简要总结
Obstructive sleep apnea (OSA) and Obesity-Hypoventilation Syndrome (OHS) are common conditions in obesity, which may influence the prognosis in patients undergoing surgery. There is a need for simple screening tools to identify such patients at high risk. The current multicenter observational study aims to investigate occurrence of OSA and OHS in obese individuals undergoing elective abdominal surgery and further address its impact on perioperative and postoperative complications.
详细描述
Obstructive sleep apnea (OSA) and Obesity-Hypoventilation Syndrome (OHS) are common conditions in obesity, which may influence the prognosis in patients undergoing surgery. There is a need for simple screening tools to identify such patients at high risk. The current multicenter observational study aims to investigate occurrence of OSA and OHS in obese individuals undergoing elective abdominal surgery by using questionnaires (STOPBANG questionnaire, Berlin Questionnaire, and Epworth Sleepiness Scale) and arterial blood gases. Perioperative and 72-h postoperative complications will be documented.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing elective abdominal surgery
- •Body-Mass-Index >=30 kg/m2
- •Ability to read and speak
- •Signed informed consent.
排除标准
- •Use of diuretics
- •Use of theophylline
- •Use of respiratory depressing drugs
- •Severe lung disease (FEV1/FVC<%50)
- •Severe hearth failure (EF<%35)
- •Central nervous system or muscle disease
- •Untreated hypothyroidism
- •Renal failure (GFR<50)
- •Total parenteral nutrition more than 72 hours
- •Hypokalemia
- •Hyponatremia
- •Hypomagnesemia
- •Hypoalbuminemia
- •Known sleep apnea or obesity hypoventilation syndrome
- •Blood transfusion from blood bank within 72 hours prior to surgery
结局指标
主要结局
Postoperative complications
时间窗: 72 hours
次要结局
未报告次要终点