NCT02791360
Completed
Not Applicable
Evaluation of Anatomy, Clinical and Neuropsychological Long-term Sequelae of Patients Treated With Radiation Therapy for Brain Tumor
Centre Francois Baclesse1 site in 1 country15 target enrollmentJanuary 2016
ConditionsBrain Neoplasms
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Neoplasms
- Sponsor
- Centre Francois Baclesse
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Proportion of patient with MRI abnormality
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Through this study, the investigators believe to describe more accurately the damage caused by brain radiation therapy in the long term.
Investigators
Eligibility Criteria
Inclusion Criteria
- •In the case group:
- •A history of solid brain tumor or haematological histologically proven.
- •Patients previously treated with radiotherapy in this brain tumor (greater than or equal to 36 Gy dose).
- •Radiotherapy treatment on a tumor in place or operated.
- •Decline at least 10 years from the end of radiotherapy.
- •Treatment with isocentric conformal radiotherapy.
- •No other radiation therapy for locally recurrent brain metastases or new brain tumor.
- •Lack of known brain metastases or meningeal carcinomatosis.
- •For the control group:
- •Patients previously treated for cancer and disease relapse free for 10 years.
Exclusion Criteria
- •In the case group:
- •Brain radiotherapy carried out by intensity modulation technique.
- •Radiation dose less than 36 Gy on the brain.
- •Subject with against-indication to MRI.
- •For the control group:
- •Previous history of brain radiotherapy.
- •Previous history of brain surgery.
- •Central neurological disorders, such as seizures, uncontrolled.
- •For two groups:
- •Current Topics in oral chemotherapy or intravenous.
Outcomes
Primary Outcomes
Proportion of patient with MRI abnormality
Time Frame: up to 4 weeks
To evaluate the proportion of patients with at least one abnormality on an imaging test
Secondary Outcomes
- MRI diffusion abnormality(up to 4 weeks)
- MRI perfusion abnormality(up to 4 weeks)
- MRI vascular morphologic abnormalities(up to 4 weeks)
Study Sites (1)
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