Validation Of A New Method To Simultaneously Measure Protein Digestion And Absorption
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Heart Failure
- Sponsor
- Texas A&M University
- Enrollment
- 74
- Locations
- 1
- Primary Endpoint
- protein metabolism in gut
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of the present study is to validate a new method in healthy volunteers and those diagnosed with COPD and CHF that is able to measure protein digestion and absorption simultaneously. This method is used to quantify digestion and absorption in patients who are suspect of impaired digestion and absorption resulting in loss of nutrients.Findings may be used to develop treatment strategies to improve protein digestion and absorption in these patient groups.
Detailed Description
The study involves 1 screening visit of approximately 1-2 hours and 1 test day of approximately 8 hours. On the study day protein digestion and absorption will be measured using a mixture of amino acids that are made slightly heavier than normal, called stable isotopes. Subjects will receive feeding by sips to monitor changes in digestion and absorption, which can be picked up by stable isotope technology.
Investigators
Marielle PKJ Engelen, PhD
PhD
Texas A&M University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
protein metabolism in gut
Time Frame: In postabsorptive and prandial state every 20 minutes up to 8 hours before each sip feeding on study day
Digestion of the stable tracers of amino acid measured by plasma samples
Secondary Outcomes
- Body Composition(on screening or study day 1)
- Respiratory muscle strength(on study day 1)
- Skeletal muscle strength of hand(30 minutes on screening or study day)
- Skeletal muscle strength of leg(30 minutes on screening or study day)