Serum Levels of Fibroblast Growth Factor 23 and Sclerostin in Relation to Serum Calcium Level in COVID 19 Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- changes in FGF23 levels
研究概览
简要总结
Hypocalcemia is associated with COVID-19 patients and is linked to poor prognosis, Fibroblast growth factor 23 (FGF23) and Sclerostin inhibit vitamin D activation and are linked to hypocalcemia.
Levels of FGF23 and Sclerostin in COVID-19 patients will be detected and correlated to calcium levels.
详细描述
COVID 19 is a current worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2 "SARS-CoV-2". Hypovitaminosis D and hypocalcaemia have been reported to be associated with COVID 19 infection, they are considered good biomarkers of clinical severity of COVID 19. Poor prognosis related to hypocalcemia is increased in elderly patients.
Fibroblast growth factor 23 and sclerostin are secreted from the bone, they decrease active vitamin D levels. Their levels and their relation to calcium levels in COVID-19 patients will be detected.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Positive COVID 19 (Mild to moderate - severe to critical).
排除标准
- •known diagnosis of CKD.
- •Known parathyroid disease.
- •Use of phosphate binder therapy within the past 3 months.
- •Use of calcium therapy within the past 3 months
- •Treatment with 25(OH) vitamin D or 1,25 (OH)(2) D
- •Underlying metabolic bone disease.
- •Underlying renal phosphate wasting disorder.
结局指标
主要结局
changes in FGF23 levels
时间窗: 6 months
Expected higher FGF23 levels in COVID 19 patients compared to control
Changes in parathyroid hormone levels
时间窗: 6 months
Expected lower levels in COVID 19 patients compared to control
Changes in serum calcium levels
时间窗: 6 months
Expected lower serum calcium levels in COVID 19 patients compared to control
changes in sclerostin levels
时间窗: 6 months
Expected higher sclerostin levels in COVID 19 patients compared to control
次要结局
- Relation between sclerostin and calcium levels(6 months)
- Relation between FGF 23 and calcium levels(6 months)
研究者
Asmaa Abdel-mageed Muhammed
Lecturer
Aswan University Hospital