ISRCTN12426682Active, not recruiting未知
Monitoring ototoxicity in patients undergoing treatment with platinum-based chemotherapy for sarcoma and testicular cancer using tablet-based self-administered audiometry and serum biomarkers
niversity College London0 sites23 target enrollmentStarted: April 6, 2022Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 23
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Patients diagnosed with sarcoma (male or female) or testicular cancer (male) and selected for platinum-based chemotherapy
- •2. Aged between 13 and 40 years
- •3. Able to provide informed consent
- •4. Able to understand and cope with the use of headphones and self-administered hearing assessments (as assessed by the researcher at informed consent)
- •5. No recent history of ear disease, e.g., acute otitis media, otitis media with effusion, middle ear surgery
- •6. Hearing at screening better than 40 dB across the following frequencies: 0.25, 0.5, 1, 2, 4 and 8 kHz
Exclusion Criteria
- •1. Prior platinum-based chemotherapy within 5 years prior to study cycle 1, day 1
- •2. Abnormalities of the external or middle ear revealed by otoscopy at screening: otitis externa, otitis media, visible tympanic membrane perforation
- •3. Conductive hearing loss, a ‘true’ air-bone gap =15 dB HL in three or more contiguous frequencies between 0.5, 1, 2, 4 kHz
Investigators
Similar Trials
Not yet recruiting
Not Applicable
A prospective study on the management of tympanic membrane retraction pockets by excision and cartilage tympanoplastyCTRI/2019/02/017686JLN Medical College Ajmer
Completed
Not Applicable
Randomized Trial Comparison of Ototoxicity Monitoring ProgramsCisplatin OtotoxicityHearing LossNCT02099786VA Office of Research and Development47
Completed
Not Applicable
Ototoxicity and hearing outcome in pediatric oncology patients receiving cisplatisensorineural hearing lossototoxicityototoxicitycisplatinThai pediatric solid tumorslong term outcomeTCTR20210221001none47
Recruiting
Not Applicable
Auriclotherapy on stress, anxiety and depression after mastectomyIRCT20091219002889N13Esfahan University of Medical Sciences70
Completed
Not Applicable
STUDY TO ASSESS HEARING LOSS IN PATIENTS RECEIVING SIMULTANEOUS CHEMOTHERAPY AND RADIATION THERAPY FOR HEAD AND NECK CANCERSCTRI/2014/08/004940FATHER MULLER MEDICAL COLLEGE50