Effect of Dumbbell Exercise on Arteriovenous Fistula in Patients With Hemodialysis：A Prospective Randomized,Controlled Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Changes in blood flow of AVF draining vein
研究概览
简要总结
Isometric exercise has been shown to increase the diameter and the blood flow rate of forearm veins.At present, more studies focus on the perioperative period to promote the maturation of arteriovenous fistula(AVF), while there are few reports on functional maintenance measures for the patients with maintenance hemodialysis.This study aims to explore the effect of dumbbell exercise on AVF，and evaluate whether patients can carry a 6-pound item with the fistula limb in a reasonable way.
详细描述
Autologous arteriovenous fistula (AVF) is the preferred vascular access for maintenance hemodialysis patients. It is estimated that AVF accounts for 85-90% of the permanent vascular access in Chinese hemodialysis patients. With the prolongation of dialysis time, aging, and the increase of diabetes incidence, the complications of AVF are more and more common, which affect the lifetime of AVF. Therefore,self-maintenance of AVF is essential. Among them, exercise should be used throughout the entire process of AVF use for the reason that it is economical, easy to operate, and highly repeatable.The most common isometric exercise is handgrip exercise. However, there are some deficiencies in this exercise, such as lack of quantitative standards and burnout of repeated actions. As a result, this study uses quantitative dumbbells as a training tool to explore the effect of dumbbell exercise on the maintenance of AVF, and further evaluates and breaks the nursing routine of "no lifting weights" of fistula limb.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have established arteriovenous fistula
- •Patients whose muscle strength of the fistula limb is graded 4-5, which can overcome the 6-pound gravity and external resistance to complete the range of joint activity
- •Patients who provided informed consent.
排除标准
- •Left ventricular cardiac ejection fraction <30%;
- •Using a arteriovenous graft or a long-term catheter as a permanent access;
- •The diameter of the aneurysm is greater than 2 cm or the aneurysm has a risk of rupture;
- •Participation in other clinical trials at the same time;
- •Severe cardiovascular diseases and other organ complications,malignant tumors, mental illnesses, etc.
研究组 & 干预措施
The handgrip exercise
Patients are asked to squeeze a rubber ring 30 times per min for altogether 20 minutes on non-dialysis days.The 20-minute exercise can be divided into 3 parts according to individual circumstances.
干预措施: The handgrip exercise (Behavioral)
The dumbbell exercise
Patients are asked to hold 6-pound dumbbells to exercise 30 times per min for altogether 20 minutes on non-dialysis days.The 20-minute exercise can be divided into 3 parts according to individual circumstances.
干预措施: The dumbbell exercise (Behavioral)
结局指标
主要结局
Changes in blood flow of AVF draining vein
时间窗: from Baseline to 3 months
The blood flow measurement was repeated three times at a location 5 cm proximal to the anastomosis in the draining vein by Doppler ultrasound.
次要结局
- Changes in blood flow of AVF proximal artery(from Baseline to 3 months)
- The ratio of pre-pump arterial pressure and blood flow(from Baseline to 3 months)
- Adverse event(from Baseline to 3 months)
- Changes in blood flow of brachial artery(from Baseline to 3 months)
- Changes in diameter of AVF draining vein(from Baseline to 3 months)