NCT06798142Active, not recruitingNot Applicable
Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat Poisoning: A Multi-Center Cohort Study
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School1 site in 1 country193 target enrollmentStarted: February 1, 2022Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 193
- Locations
- 1
- Primary Endpoint
- Survival outcome
Study Overview
Brief Summary
This ambispective cohort study aims to characterize the relationship between plasma diquat concentrations and organ damage risk.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Other
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •history of oral exposure to diquat solution reported by patient or proxy;
- •a specimen for the diquat plasma concentration collected immediately upon admission;
- •documentation that patients or, in case of unconsciousness of the patient, legal proxies were aware of and agreed to treatment plans.
Exclusion Criteria
- •they had ingested other toxins in addition to diquat (qualitative toxicological screening tests);
- •diquat was not detected in specimens, or plasma concentration data were unavailable;
- •patients with an exposure time (time from exposure to emergency department presentation) longer than 48 hours;
- •data on organ damage were not unavailable;
- •combined with other central nervous system injuries other than toxic encephalopathy.
Outcomes
Primary Outcomes
Survival outcome
Time Frame: 28 days within the index date of presentation at emergency department
Secondary Outcomes
No secondary outcomes reported
Investigators
Hao Sun
Principal Investigator
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study Sites (1)
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