NCT03996824招募中不适用
Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- AAV transduction in inner ear cells
研究概览
简要总结
Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.
This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient ≥ 18 years old
- •Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient
- •Informed consent obtained
- •Patients with a french social protection (AME excluded)
排除标准
- •Intravestibular or intra-cochlear extension of the tumor
- •Pregnant woman
- •Patient with administrative control
- •Medical contra-indication
结局指标
主要结局
AAV transduction in inner ear cells
时间窗: 10 days
The transduction will be measured with immunostaining techniques
次要结局
未报告次要终点
研究者
研究点 (2)
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