Effects of involuntary breathing movements on central blood flow
- Conditions
- healthy proband:in
- Registration Number
- DRKS00028611
- Lead Sponsor
- DLR, Deutsches Zentrum für Luft- und Raumfahrt
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Age = 18 years
Ability to hold breath till onset of IBMs
Pregnancy (will be tested during medical examination) MR Exclusion Criteria o Metal implants or other osteosynthesis material, stents, clips, etc. that are not MRI compatible or interfere with the examination due to their location. o Pacemakers, infusion pumps, neurostimulators, inner ear implants. o Claustrophobia. o Permanent makeup or tattoos that are not suitable for MRI. o Piercings that cannot be removed. Any clinical abnormality on medical examination o Current diseases of vital organs or the central nervous system. o Psychiatric disorders that might prevent subjects from consenting to the examination or complying with the protocol. protocol. o Regular use of medications that could affect the outcome of the study (hormonal contraceptives are not a criterion for exclusion). o Regular consumption of alcohol (20-30 g/day), nicotine (>3 cigarettes/day) or illicit drugs in Germany. o Blood donation within 3 months for women and 2 months for men prior to the study. o Clinically relevant findings in the ECG such as second or third degree AV block, prolongation of the QRS complex over 120 ms or the QTc interval over 450 ms. o Supine hypertension (> 140/90 mmHg) or hypotension (< 90/50 mmHg).
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoint <br>Change in average blood flow in four main vessels (V. cava inferior, Tr. pulmonalis, Aorta <br>ascendens, A. carotis internal) between at least two of the following time points: baseline – <br>early apnea – early IBMs – middle IBMs – late IBMs – recovery. One endpoint for each vessel.
- Secondary Outcome Measures
Name Time Method Secondary endpoints <br>Change in average blood flow differences during breathing (inspiration – expiration) in the <br>above-mentioned vessels between at least two of the following time points: baseline – early <br>IBMs – middle IBMs – late IBMs – recovery. One endpoint for each vessel. <br>Change in average arterial pressure (mean, systolic, diastolic) between at least two of the <br>following time points: baseline – early apnea – early IBMs – middle IBMs – late IBMs – recovery. <br>One outcome for each measure. <br>Change in average heart rate between at least two of the following time points: baseline – early apnea – early IBMs – middle IBMs – late IBMs – recovery. <br>Change in average peripheral oxygen saturation between at least two of the following <br>time points: baseline – early apnea – early IBMs – middle IBMs – late IBMs – recovery.