NCT05769699招募中不适用
Serum Biomarkers in Parkinson's Disease at Different Stages
Fondazione Policlinico Universitario Agostino Gemelli IRCCS2 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2022年2月10日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Determine biooogical characteristics of parkinsonian patients in various stages of disease
研究概览
简要总结
- Determine clinical characteristics of parkinsonian patients in various stages of disease;
- Measure peripheral neurodegeneration, synaptic, and inflammation biomarkers in a population of parkinsonian patients at various stages of disease.
- Measure vesicular neurodegeneration, synaptic and inflammation biomarkers
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with idiopathic PD according to Movement Disorders Society (MDS) criteria;
- •Age: 18-80 years;
- •Signature of informed consent to participate in this study
- •Exclusion criteria.
- •Women pregnant
- •Inflammatory or autoimmune diseases
排除标准
- 未提供
结局指标
主要结局
Determine biooogical characteristics of parkinsonian patients in various stages of disease
时间窗: 3 years
dosage of serum IL-1b, IL6, IL-5, IL-4, IL17, TNFa, IFNg, IL10, total-alpha-synuclein, NfL, BDNF (ng/ml for all)
Determine clinical characteristics of parkinsonian patients in various stages of disease
时间窗: 3 years
Determine clinical characteristics of parkinsonian patients in various stages of disease by means of MDS-UPDRS score changes.
次要结局
未报告次要终点
研究者
研究点 (2)
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