NCT07669402已完成2 期
Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia: A Three-Arm Randomized Clinical Trial.
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
研究概览
简要总结
This is a randomized clinical trial evaluating the efficacy of Letrozole, L-Carnitine, and their combination on sperm quality, oxidative stress, and ART outcomes in men with idiopathic oligoasthenoteratozoospermia.
详细描述
This three-arm randomized controlled trial included 90 men with idiopathic oligoasthenoteratozoospermia (iOAT) who were assigned to receive Letrozole (2.5 mg/day), L-Carnitine (1000 mg/day), or combination therapy for 3 months. Sperm parameters, hormonal profiles, oxidative stress biomarkers, mitochondrial function, and ICSI outcomes were assessed before and after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
All participants, care providers, investigators, and outcome assessors were blinded to group allocation.
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of idiopathic oligoasthenoteratozoospermia (iOAT) per WHO 2021 criteria
- •Age 20 to 45 years
- •BMI between 18 and 30 kg/m²
- •No prior hormonal therapy or antioxidant supplements within the last 3 months
排除标准
- •Varicocele, cryptorchidism, or genital tract infection
- •Hormonal disorders (hypogonadism, hyperprolactinemia, thyroid dysfunction)
- •Smoking, alcohol use, or drug abuse
- •Use of testosterone or anabolic steroids within the last 6 months
- •Female partner with severe infertility factors (age ≥40, tubal blockage, severe endometriosis)
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
3 期
Treatment of hypothyroidism with ayurveda medicine Ghanadi vati & Kanchnara gudikaCTRI/2025/11/096889Dr Divya Singh Charan90
尚未招募
2 期
Comparing Ayurvedic Eye Drops and Eye Application in ConjunctivitisCTRI/2026/02/104432Dr Sumi S100
尚未招募
2/3 期
Comparing Two Ayurvedic Treatments- Yashtimadhu churna and Pippali madhu yoga for Acid Reflux(Urdhwag Amlpitta)CTRI/2026/02/104489Dr Mrunal Chandrakant Nawkar88
尚未招募
不适用
Comparison of two ayurvedic local treatments in patients after piles surgeryCTRI/2026/02/103855Dr Jinal Goti50
尚未招募
2 期
Evaluation of Basti treatment for thin endometrium.CTRI/2026/01/102436Dr Navneet40