Long term sugar control in liver disease patients with outcome in postoperative liver transplant

Completed

Conditions: Liver transplant patients operated for chronic liver disease

Registration Number: CTRI/2018/04/012966

Lead Sponsor: Institute of Liver and Biliary Science New Delhi

Brief Summary: **Background:** There is high prevalence of DM (Diabetes mellites) in patients of cirrhosis. Diabetes has been implicated for complication in post-transplant patients. Glycated haemoglobin(HbA1c) is now targeted as a modifiable risk factors for postoperative complications. **Aims:** In this retrospective study we looked for co-relation between preoperative HbA1c level and post-operative mortality and morbidity in patients of liver transplant (LT). **Material and methods:** Retrospective data for adult patients operated upon for LT was retrieved. Patients were divided into 2 groups on the basis of HBA1c levels (Group1-less than; Group 2-equal to more than 6.5%) **Results**: 400 patients were operated for LT. After exclusion data was analysed for 224 patients. 72(32%) had DM. Patients with DM had higher body mass index (24.3Â±4.9). Insulin requirement was higher in Group 2. No correlation was seen for HBA1c levels and postoperative cardiovascular, renal, central nervous complications. No difference was seen between 2 groups for duration of surgery, volume of blood loss, need for renal replacement therapy, incidence of infections, rejection, need for re-exploration surgery and duration of ICU, hospital stay and survival between this two groups. **Conclusion:** Diabetes mellitus is seen in around one third of patients with cirrhosis of liver. Presence of diabetes does not add to post-operative complication in liver transplant patients. Uncontrolled DM remains insulin depended after transplant

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 400

Inclusion Criteria

Patients operated for Liver transplant From 2010 to September 2016 were included.

Exclusion Criteria

Patients with age less than 18 years, Incomplete medical records, Patients operated for acute on chronic liver failure, and for acute liver failure were excluded.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
preoperative HbA1c level and post-operative mortality and morbidity in patients of liver transplant	During stay in intensive care unit

Secondary Outcome Measures

Name	Time	Method
Data was also collected for insulin requirement, need for renal replacement therapy, infections, episodes of cellular rejection requiring steroid pulse therapy, duration of mechanical ventilation, need for re-exploration surgery and duration of ICU and hospital stay.	During stay in intensive care unit

Trial Locations

Locations (1): Institute of Liver and Biliary Science
🇮🇳
Delhi, DELHI, India
Institute of Liver and Biliary Science
🇮🇳Delhi, DELHI, India
Dr Mohd Qurram Parveez
Principal investigator
9914749048
drqurramparvez@gmail.com