Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)

Phase 1

Completed

• Conditions: Primary Liver Cancer
• Interventions: Procedure: MRI of the liver before start of treatment; Procedure: MRI after treatment; Procedure: PET-scan before treatment start; Procedure: PET scan after treatment

• Registration Number: NCT01116804
• Lead Sponsor: University Hospital, Ghent

Brief Summary

Present imaging modalities for primary liver cancer (hepatocellular carcinoma or HCC) have several shortcomings. One important shortcoming is the time delay between successful treatment and radiological confirmation of this response. Often it takes several months for anatomical changes to occur and to be appreciated on morphological imaging such as CT or MRI (shrinkage of tumor, absence of contrast enhancement). Functional imaging by means of Fluor-18 deoxyglucose or Fluor-18 Choline (positron emitters, PET-scan) might be an early indicator of response. This "early" information might help to tailor treatment. For instance, if no response is induced, an early switch in therapy can be planned.

The present study investigates whether the routine PET-tracer (Fluor-18 deoxyglucose) and the experimental PET-tracer, Fluor-18 Choline help to predict response if a patient with inoperable primary liver cancer is treated (radionuclide therapy, biologicals).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-05-03
• Study First Submitted QC: 2010-05-04
• Study First Posted: 2010-05-05
• Study Start: 2010-06-16
• Primary Completion: 2020-01-20
• Study Completion: 2020-01-20
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-13
• Last Update Posted: 2022-12-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
inoperable liver cancer patients	MRI after treatment	-
inoperable liver cancer patients	MRI of the liver before start of treatment	-
inoperable liver cancer patients	PET-scan before treatment start	-
inoperable liver cancer patients	PET scan after treatment	-

Primary Outcome Measures

Name	Time	Method
To evaluate the efficacy of PET-imaging versus classic response assessment (MRI, CT-scam) in patients with inoperable liver cancer	6 months after start of treatment

Trial Locations

Locations (1)

University Hospital Ghent; 🇧🇪 Ghent, Belgium