The effect of intravenous tranexamic acid on blood loss after vaginal delivery

Not Applicable

• Conditions: postpartum haemorrhage.; Other immediate postpartum haemorrhage

• Registration Number: IRCT2012072910324N2
• Lead Sponsor: Womens Reproductive Health Research center, Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

-Women with singleton pregnancy between 38 to 42 weeks
- Cephalic presentation
- No history of cesarean section or uterine surgery
- No history of uterine myoma
- Normal blood pressure
- No history of postpartum haemorrhage
- No history of coagulation disorders
- No history of heart disease
- No history of renal disease
- No history of blood disorders and anemia
- No history of cerebrovascular disease
- Absence of diabetes and preeclampsia in pregnancy current
- Absence of polyhydramnious of macrosomia in the current pregnancy
- lack of long-term induction of labor in first stage
Exclusion criteria:
- Instrumental delivery
- Extensive vaginal and cervical lacerations
- Need for placenta curettag
- Continuous pressure in the fundus of the uterus before the fetus and placenta expulsion.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of measured blood loss after delivery in the intervention group (receiving tranexamic acid and oxytocin) and control group ( receiving placebo of tranexamic acid and oxytocin). Timepoint: first two hours after delivery. Method of measurement: Differences between the weight of the full and empty container and the dry and bloody plastic cover, drapes and quaze pads will be recorded during the first two hours after delivery and blood loss will be assessed by the method of Gai et al.;Comparison of the calculated blood loss after delivery in the intervention group (receiving tranexamic acid and oxytocin) and control group ( receiving placebo tranexamic acid and oxytocin). Timepoint: Before and 12-24 hours after delivery. Method of measurement: Calculated blood loss will be assessed according to pre- and post delivery hematocrit.