Next-Generation Sequencing via Tissue and Liquid Biopsy in Patients with Metastatic Pancreatic, Biliary, and Colorectal Cancers: Correlation with Therapeutic Response

Pancreatic and Biliary tract and colorectal cancers represents a group of gastrointestinal malignancies with distinct etiologies but share common challenges in metastatic settings limited treatment options and  modest survival outcomes and last stage diagnosis and  Pancreatic Ductal Adenocarcinoma and Biliary tract cancers typically present at advanced stage with median overall survival rarely  exceeding 12 months even with combination of chemotherapy regime  then in this study we want to learn about genetic changes in patients with these type of cancers and we will do it by analysing samples from tumour tissue and blood samples using methods called Next Generation Sequencing and This research may help us to understand how certain gene changes affect how will patients respond to the cancer treatments and Purpose of the studies to find out certain genetic  changes in cancers patients can predict how well they will respond to the and see if simple blood test mean liquid biopsy gives similar results to a tissue biopsy Furthermore to check if regular blood test during treatment can help us to see the cancer is responding and if it is becoming resistant to the treatment