IRCT20151106024901N5已完成3 期
Clinical efficacy of Mesalazine in patients with diarrhea-dominant irritable bowel syndrome with elevated fecal calprotectin referred to Emam Reza Hospital of Tabriz: a randomized double-blind, placebo-controlled trial
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 no limit（—）
- 性别
- All
入选标准
- •Patients with IBS-D according to ROME IV criteria (Loose and watery stool at at least 25% and hardy stool less than 25% of bowel movement)
- •Age over 18 years
- •Predominant symptom of diarrhea
- •Calprotectin levels above 50 feces
- •Normal colonoscopy during the last 5 years
排除标准
- •Pregnancy and lactation and those who plan to become pregnant
- •History of major abdominal surgery other than appendectomy and cholecystectomy
- •A history of allergic disease such as asthma in yourself or a first-degree relative
- •Celiac disease
- •History of known psychological disease
- •Consumption of anti-inflammatory drugs (corticosteroids, NSAIDs), mast cell stabilizers and antibiotics in the last 3 months
- •History of inflammatory bowel disease or ulcerative colitisSensitivity to sulfur-containing compounds such as mesalazine
- •Consumption of lactulose and recent probiotics
- •Evidence of organic disease in colonoscopy
- •Normal stool calprotectin
研究者
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