Study on the Impact of Cardiac Rehabilitation Training on the Quality of Life and Cognitive Function in Atrial Fibrillation Patients
- Conditions
- Diseases of the circulatory system
- Registration Number
- KCT0009082
- Lead Sponsor
- Pohang Semyung Christianity Hospital
- Brief Summary
Background: Long-term aerobic exercise is known to improve cognitive function and quality of life in both normal individuals and patients with cognitive impairment. However, there has been no research on whether this effect is also observed in patients with atrial fibrillation accompanied by cognitive impairment. Therefore, this study aimed to confirm the improvement of cognitive function after exercise training in patients with atrial fibrillation and cognitive impairment through a randomized controlled trial and evaluate its effects. Method: Fifty-one patients with atrial fibrillation (32 males, 19 females, mean age 64±6 years) were randomly assigned to a 16-week continuous aerobic interval training (CT) group or a control group (MT). Aerobic rehabilitation training was conducted three times a week for 1 year or 6 months at an intensity of 85-95% of the maximum heart rate. The primary outcome variable was the change in the Mini-Mental State Examination after 16 weeks. Results: Sixteen weeks of aerobic exercise training improved the Mini-Mental State Examination (CT: 21.2 ± 5.1 vs. MT: 18.4 ± 6.3, p<.05). The secondary outcome variable, maximum oxygen consumption, also significantly improved (CT: 26.2 ± 4.1 vs. MT: 21.4 ± 5.7 ml/kg/min). However, the secondary outcome variable, changes in middle cerebral artery blood flow velocity, did not show significant differences in either group. Conclusion: Sixteen weeks of aerobic training improved cognitive function in patients with atrial fibrillation accompanied by cognitive impairment. To maintain these improvements, healthcare professionals should continuously recommend physical activity to patients with atrial fibrillation and develop individualized programs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 64
From the patient medical records, adults with paroxysmal or persistent AF who were willing to participate in a training program and agreed to sign an informed consent form were included
The exclusion criteria were: engagement in high-intensity endurance training three times per week or more; class III or IV heart failure per the New York Heart Association Classification; history of open-heart surgery; left ventricular ejection fraction (LVEF) =40%; severe refractory hypertension; severe cardiac valve disease; moderate or severe pulmonary disease; mental disorder; and an inability to exercise due to a musculoskeletal disorder.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mini-Mental State Examination_Korean version
- Secondary Outcome Measures
Name Time Method Exercise capacity, quality of life, physical activity level, cardiac function