Evaluation of Skeletal Muscle Function in Patients With Chronic Obstructive Pulmonary Disease Before and After Lung Rehabilitation Training Using Ultrasonic Elastography

China-Japan Friendship Hospital0 sites60 target enrollmentApril 7, 2023

ConditionsChronic Obstructive Pulmonary Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Chronic Obstructive Pulmonary Disease
Sponsor: China-Japan Friendship Hospital
Enrollment: 60
Primary Endpoint: Effectiveness of pulmonary rehabilitation training
Status: Not yet recruiting
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography.

Participants will undergo pulmonary rehabilitation.

Registry

clinicaltrials.gov

Start Date

April 7, 2023

End Date

December 31, 2024

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

China-Japan Friendship Hospital

Responsible Party

Principal Investigator

Gang Hou

Principal Investigator

China-Japan Friendship Hospital

Eligibility Criteria

Inclusion Criteria

•The age is between 40-80 years old
•Patients with chronic obstructive pulmonary disease who meet the diagnostic criteria of GOLD guideline(2019)
•There was no acute exacerbation in the past 12 weeks

Exclusion Criteria

•Hypoxemia (oxygen partial pressure is less than 60mmHg or oxygen saturation is less than 88% at rest), or patients who need continuous oxygen inhalation, or patients with any contraindication to exercise test (refer to the American Thoracic Association/American Association of Thoracic Physicians exercise test guidelines)
•Oral glucocorticoids
•Receive long-term oxygen therapy prescription
•Have participated in supervised exercise programs in the past 12 months
•History of other lung diseases, including pneumoconiosis, bronchiectasis, tuberculosis, primary pulmonary hypertension, pulmonary embolism, interstitial lung disease
•Diseases that restrict the active exercise ability of participants or involve skeletal, neuromuscular, cardiovascular or metabolic disorders of muscle activity, such as tumors, diabetes, muscle weakness, etc

Outcomes

Primary Outcomes

Effectiveness of pulmonary rehabilitation training

Time Frame: 1 week after pulmonary rehabilitation

6-30-second sit-to-stand test

Secondary Outcomes

Forced Expiratory Volume in 1-second(FEV1)(1 week after pulmonary rehabilitation)
Ultrasonic elastic imaging of rectus femoris(1 week after pulmonary rehabilitation)