NCT05805332
Not yet recruiting
Not Applicable
Evaluation of Skeletal Muscle Function in Patients With Chronic Obstructive Pulmonary Disease Before and After Lung Rehabilitation Training Using Ultrasonic Elastography
China-Japan Friendship Hospital0 sites60 target enrollmentStarted: April 7, 2023Last updated:
ConditionsChronic Obstructive Pulmonary Disease
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- China-Japan Friendship Hospital
- Enrollment
- 60
- Primary Endpoint
- Effectiveness of pulmonary rehabilitation training
Overview
Brief Summary
The goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography.
Participants will undergo pulmonary rehabilitation.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 40 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •The age is between 40-80 years old
- •Patients with chronic obstructive pulmonary disease who meet the diagnostic criteria of GOLD guideline(2019)
- •There was no acute exacerbation in the past 12 weeks
Exclusion Criteria
- •Hypoxemia (oxygen partial pressure is less than 60mmHg or oxygen saturation is less than 88% at rest), or patients who need continuous oxygen inhalation, or patients with any contraindication to exercise test (refer to the American Thoracic Association/American Association of Thoracic Physicians exercise test guidelines)
- •Oral glucocorticoids
- •Receive long-term oxygen therapy prescription
- •Have participated in supervised exercise programs in the past 12 months
- •History of other lung diseases, including pneumoconiosis, bronchiectasis, tuberculosis, primary pulmonary hypertension, pulmonary embolism, interstitial lung disease
- •Diseases that restrict the active exercise ability of participants or involve skeletal, neuromuscular, cardiovascular or metabolic disorders of muscle activity, such as tumors, diabetes, muscle weakness, etc
Outcomes
Primary Outcomes
Effectiveness of pulmonary rehabilitation training
Time Frame: 1 week after pulmonary rehabilitation
6-30-second sit-to-stand test
Secondary Outcomes
- Forced Expiratory Volume in 1-second(FEV1)(1 week after pulmonary rehabilitation)
- Ultrasonic elastic imaging of rectus femoris(1 week after pulmonary rehabilitation)
Investigators
Gang Hou
Principal Investigator
China-Japan Friendship Hospital
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