NCT03898752已完成不适用
Is Oxidative Stress in Semen Reduced by Lifestyle Intervention
Peter Humaidan2 个研究点 分布在 1 个国家目标入组 31 人开始时间: 2018年11月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Oxidative stress
研究概览
简要总结
In this study we aim to investigate whether a 3-month life-style intervention would reduce oxidative stress (OS) in semen in men of infertile couples attending IVF-treatment. Men with a DFI above 15% (SCSA method) are recruited for intervention with a 3-month follow-up.
It is hypothesized that men who also have a OS above 1.34 using a novel OS diagnostic method (MiOXSYS) respond better to antioxidant treatment with a change in OS and DFI. The primary outcome is the change in OS following the intervention. Secondary outcomes are morphological semen parameters and DNA fragmentation index.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Attending IVF treatment for unknown or male factor infertility.
排除标准
- •Genetic diseases
- •Azospermia
结局指标
主要结局
Oxidative stress
时间窗: 3 months
Oxidative stress as measured with MiOxysis (Ayto Bioscience inc).
次要结局
- Semen quality(3 months)
- DNA fragmentation index(3 months)
研究者
Peter Humaidan
Professor, MD
Regionshospitalet Viborg, Skive
研究点 (2)
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