Is Oxidative Stress in Semen Reduced by Lifestyle Intervention
- Conditions
- Oligospermia
- Interventions
- Dietary Supplement: Omega 3
- Registration Number
- NCT03898752
- Lead Sponsor
- Peter Humaidan
- Brief Summary
In this study we aim to investigate whether a 3-month life-style intervention would reduce oxidative stress (OS) in semen in men of infertile couples attending IVF-treatment. Men with a DFI above 15% (SCSA method) are recruited for intervention with a 3-month follow-up.
It is hypothesized that men who also have a OS above 1.34 using a novel OS diagnostic method (MiOXSYS) respond better to antioxidant treatment with a change in OS and DFI. The primary outcome is the change in OS following the intervention. Secondary outcomes are morphological semen parameters and DNA fragmentation index.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 31
- DFI>15
- Attending IVF treatment for unknown or male factor infertility.
- Genetic diseases
- Azospermia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Lifestyle intervention Omega 3 Diet, omega-3 fish oil (1g daily), CoQ10 (100 mg/day) and a normal Multi-vitamin, Smoking cessation, weight loss, exercise,
- Primary Outcome Measures
Name Time Method Oxidative stress 3 months Oxidative stress as measured with MiOxysis (Ayto Bioscience inc).
- Secondary Outcome Measures
Name Time Method Semen quality 3 months Morphological semen parameters using WHO recommendation for semen analysis.
DNA fragmentation index 3 months DNA fragmentation index as measured by the method by SPZlab A/S (SCSA method)
Trial Locations
- Locations (1)
The Fertility Clinic Skive
🇩🇰Skive, Central Denmark Region, Denmark