Study of the Enteric Nervous System Using Colonic Biopsies in Parkinson Patients With LRRK2 Mutation
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Presence of alpha-synuclein aggregates in colonic biopsies using immunohistochemistry
研究概览
简要总结
The clinical and pathological similarities between LRRK2 related parkinsonism and idiopathic Parkinson's disease (PD) indicate that monogenetic LRRK2 parkinsonism may be a paradigm for the development of Lewy bodies disease, and a careful look at discrepancies between these two conditions may provide insight into the pathogenesis of PD. The early involvement of the enteric nervous system (ENS) during PD led to theories that an as yet unidentified external agent entering the ENS causes PD . If lesions of the ENS are found in patients who present with a genetic form of parkinsonism would go against this notion, and thus provide insight to the pathophysiology of the disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 30-80, both genders
- •Parkinson's disease patients
- •Parkinson's disease patients with G2019S mutations
- •Controls: patient at risk of colic cancer for whom a coloscopy is required
排除标准
- 未提供
结局指标
主要结局
Presence of alpha-synuclein aggregates in colonic biopsies using immunohistochemistry
时间窗: 3 months
次要结局
- Analysis of intestinal permeability in biopsies using Ussing's chambers(3 months)