Study of the Enteric Nervous System Using Colonic Biopsies in Parkinson Patients With LRRK2 Mutation
Not Applicable
Terminated
- Conditions
- Parkinson's Disease
- Interventions
- Other: colonoscopy or rectosigmoidoscopy
- Registration Number
- NCT01618383
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
The clinical and pathological similarities between LRRK2 related parkinsonism and idiopathic Parkinson's disease (PD) indicate that monogenetic LRRK2 parkinsonism may be a paradigm for the development of Lewy bodies disease, and a careful look at discrepancies between these two conditions may provide insight into the pathogenesis of PD. The early involvement of the enteric nervous system (ENS) during PD led to theories that an as yet unidentified external agent entering the ENS causes PD . If lesions of the ENS are found in patients who present with a genetic form of parkinsonism would go against this notion, and thus provide insight to the pathophysiology of the disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 19
Inclusion Criteria
- Patients aged 30-80, both genders
- Parkinson's disease patients
- Parkinson's disease patients with G2019S mutations
- Controls: patient at risk of colic cancer for whom a coloscopy is required
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Colonic biopsies colonoscopy or rectosigmoidoscopy Colonic biopsies obtained during the course of colonoscopy or rectosigmoidoscopy
- Primary Outcome Measures
Name Time Method Presence of alpha-synuclein aggregates in colonic biopsies using immunohistochemistry 3 months
- Secondary Outcome Measures
Name Time Method Analysis of intestinal permeability in biopsies using Ussing's chambers 3 months
Trial Locations
- Locations (1)
University Hospital
🇫🇷Nantes, France