Effect of Perioperative Muscle Relaxant Model on Postoperative Outcomes in Chinese Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 999
- 试验地点
- 9
- 主要终点
- Visual Analogue Scale of pain at rest at 24 hours after surgery
研究概览
简要总结
Muscle relaxant is usually needed for surgery. However, the optimal depth of neuro-muscular blockade is still on debate. Deep neuro-muscular blockade may benefit the patients during surgery, but may increase the risk of residual blockade after surgery. Residual blockade has been reported to increase risk of morbidity. In this study, we tend to observe the postoperative outcomes in patients undergoing abdominal surgery under general anesthesia. And to compare the outcomes in patients received different depth of neuro-muscular blockade.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old
- •Body mass <18 kg/m2
- •American Society of Anesthesiologists status I-II
- •Patients scheduled for elective laparoscopic colorectal or urological surgery
- •Patients received general anesthesia and muscle relaxant
- •Patients with written informed consent.
排除标准
- •Second surgery during the same admission.
- •Outpatient surgery
- •Retroperitoneal laparoscopic surgery
- •Patients scheduled for mechanical ventilation after surgery
- •Patients scheduled for muscle relaxant other than rocuronium
- •Patients with pregnancy or planned for breeding
- •Patients who are involved in other studies
结局指标
主要结局
Visual Analogue Scale of pain at rest at 24 hours after surgery
时间窗: from end of surgery to 24 hours after surgery
The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain.
Visual Analogue Scale of pain at cough at 24 hours after surgery
时间窗: from end of surgery to 24 hours after surgery
The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain.
次要结局
- Time to flatus(from end of surgery to flatus, on an average of 3 days)
- Time to extubation of the endotracheal tube(from end of surgery to removal of the endotracheal tube, on an average of 15 minutes)
- Incidence of patients suffering pain at 24 hours after surgery(from end of surgery to 24 hours after surgery)
- Incidence of major postoperative complications(from end of surgery to discharge from the hospital, on an average of 5 days)
- Satisfaction score of the Surgeon to the condition during surgery(from start of surgery to end of surgery, on an average of 2.5 hours)
研究者
Zhihong LU
Professor
Air Force Military Medical University, China