Comparative study between two ventilatory methods on the changes in air distribution in different regions of the lung in patients with severe respiratory failure
Phase 3
- Conditions
- Health Condition 1: J960- Acute respiratory failure
- Registration Number
- CTRI/2024/01/061175
- Lead Sponsor
- JIPMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age :18 - 75 years
2.Diagnosis of ARDS according to Berlin’s criteria.
a.Symptom begin within 1 week of insult, or new/worsening symptoms in last 1 week.
b.Bilateral opacities on chest imaging
c.PaO2/FiO2 < 300 while on PEEP > 5 cm H2O
d.Not fully attributed to cardiac failure and / or volume overload
3.PaO2/FiO2 <200
4.Anticipated duration of mechanical ventilation >48 hours
Exclusion Criteria
1.Contraindication for prone positioning
2.Hemodynamic instability – Requirement of two or more vasopressor infusions to maintain target MAP.
3.Already receiving prone ventilation
4.Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method