Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?

Not Applicable

Completed

• Conditions: Cholangiocarcinoma; Hepatectomy; Surgical Treatment
• Interventions: Procedure: Minor or Major Liver Resection

• Registration Number: NCT00733200
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

The investigators conducted a prospective study to determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in 138 patients with hilar cholangiocarcinoma. In selected patients, minor liver resection was a good treatment.

Detailed Description

Objective: To determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in patients with hilar cholangiocarcinoma (HC).

Summary Background Data: For HC treated with hepatectomy, the extent of liver resection remains controversial despite extensive studies.

Methods: From January 2000 to December 2007, we prospectively studied patients who received surgical treatment for HC. Of the 187 patients who were surgically treated, 138 (73.8%) underwent resection with a curative intent. Minor hepatectomy was carried out in 93 patients who had Bismuth-Corlette types I, II and III HC without hepatic artery/portal vein invasion; and major hepatectomy in 45 patients who had type III HC with hepatic artery/portal vein invasion, or type IV HC.

Study Timeline

• Status Verified: 2008-08
• Study First Submitted: 2008-08-08
• Study First Submitted QC: 2008-08-11
• Study First Posted: 2008-08-12
• Last Update Submitted: 2009-12-10
• Last Update Posted: 2009-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Criteria for resectability were absence of peritoneal or liver metastases, tumor extension to beyond secondary biliary branches bilaterally, tumor extension to secondary portal venous branches bilaterally

Exclusion Criteria

• not in accordance with the above criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	Minor or Major Liver Resection	-

Primary Outcome Measures

Name	Time	Method
On multivariate analysis, prognostic factors significantly impacted on long-term survival were UICC tumor stage and histopathologic grade.