IRCT20160813029315N2已完成2 期
Placebo-controlled randomized clinical trial testing the efficacy of desipramine in reducing craving in patients with methamphetamine use disorder
Mental Health Research Center0 个研究点目标入组 40 人开始时间: 待定最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 50 years（—）
- 性别
- Male
入选标准
- •Age between 18 to 50
- •Current diagnosis of methamphetamine use disorder based on DSM IV-TR criteria
- •Positive urine test for methamphetamine prior to study entry
- •Male gender
排除标准
- •Having conditions known to be deteriorated following desipramine use such as obesity, liver diseases, and cardiovascular diseases
- •Taking antidepressants of any class in during the two weeks prior to entering the study
- •Taking medications with potential effect on methamphetamine craving (i.e. modafinil, bupropion, naltrexone, N-acetylcysteine)
- •Taking medications known to adversely interact with desipramine
- •Serious mood disorders, suicidal ideation, and psychotic disorders requiring hospitalization
- •Comorbid medical conditions, as revealed by history review, physical exam, or laboratory results of blood chemistry test and liver profile
- •Incidence of a life-threatening side effect following medication use (i.e. liver failure, pancreatitis, hepatic encephalopathy, thrombocytopenia, leucopenia)
- •Medication intolerance
- •Use of other substances (except methadone maintenance therapy, nicotine, cannabis, and morphine) confirmed by a toxicology screen
- •Currently (during a month prior to study) in treatment for methamphetamine use
- •Having DSM IV-TR diagnosis of other substance use disorders in the past year
- •No longer willing to participate in the study
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