Assessing antibiotic therapy in ICU patients with infections

Recruiting

• Registration Number: CTRI/2023/08/056619
• Lead Sponsor: Hari Naveen Ashok Kumar

Brief Summary

We seek to evaluate appropriateness of empirical antibiotic therapy for community acquired infections in critically ill patients and its effect on outcomes. We also seek to evaluate our concordance with current guidelines.

Primary outcomes measured are mortality at 28 days. Secondary outcomes are ventilator free days, vasopressor free days, renal replacement free days at 28 days and length of ICU stay and hospital stay. ICMR guidelines and ISCCM guidelines for tropical illness are used to compare concordance.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-08-18
• Study Start: 2023-08-28

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

1.All adults patients admitted into ICU from ER with suspicion of community acquired infection and started on empirical antibiotics 2.Antibiotics started within 48 hours of admission to ICU and continued for atleast 24 hours.

Exclusion Criteria

1.Patients with indwelling catheters (central venous catheters, haemodialysis catheters, urinary catheters, chemo port, peripherally inserted central catheter, etc) prior to admission 2.History of hospitalization for more than 2 days in the preceding 30 days 3.History of Antibiotic usage in the preceding 30 days.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Concordance with current guidelines	28 days
2.Appropriateness of empirical antibiotic therapy & its effect on Mortality at 28 days	28 days

Secondary Outcome Measures

Name	Time	Method
•Appropriateness of empirical antibiotic therapy & its effect on ventilator free days at 28-day, vasopressor free days at 28-day, renal replacement therapy free days at 28-day, length of ICU stay and length of hospital stay	28 days

Trial Locations

Locations (1)

Apollo Hospital; 🇮🇳 Chennai, TAMIL NADU, India

Apollo Hospital

🇮🇳Chennai, TAMIL NADU, India

Dr Hari Naveen Ashok Kumar

Principal investigator

9940537733

harinaveen19@gmail.com