Treatment Response to Rehabilitation in Patients With Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia
• Interventions: Behavioral: Cognitive Remediation; Behavioral: Computer-skills training

• Registration Number: NCT00063336
• Lead Sponsor: Hartford Hospital

Brief Summary

This study will examine the ways in which schizophrenia-related symptoms affect response to a rehabilitation program for people with schizophrenia.

Detailed Description

Patients with schizophrenia often suffer neurocognitive impairment and psychosocial and vocational difficulties. This study will help identify those patients most likely to benefit from existing behavioral treatments and provide clues for how to modify treatments for those who do not benefit.

Two studies will be conducted. The first will investigate the relationship of symptoms and neurocognitive variables at study entry to psychosocial and vocational status 2 years later. The second study will investigate the relationship of symptoms and neurocognitive variables at study entry to treatment response in patients assigned to either a cognitive remediation track or a computer skills track as part of their rehabilitation treatment.

Both the cognitive remediation and computer skills training programs will last 4 to 6 months. Participants will be assessed pre- and post-treatment. Neuropsychological, psychosocial and vocational status will be measured.

Study Timeline

• Study Start: 2001-12
• Study First Submitted: 2003-06-25
• Study First Submitted QC: 2003-06-26
• Study First Posted: 2003-06-27
• Primary Completion: 2005-11
• Study Completion: 2005-11
• Status Verified: 2009-05
• Last Update Submitted: 2013-11-07
• Last Update Posted: 2013-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• DSM-IV criteria for schizophrenia or schizoaffective disorder
• In need of intensive outpatient care
• Treatment with atypical antipsychotic medication for a minimum of 6 months prior to study entry

Exclusion Criteria

• Auditory or visual impairment
• Mental retardation (IQ less than 70)
• Traumatic brain injury with loss of consciousness
• Presence or history of any neurological illness that may affect brain physiology
• Lack of proficiency in English
• Concurrent substance abuse and/or dependence

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Cognitive Remediation	Participants will receive cognitive remediation treatment.
2	Computer-skills training	Participants will receive computer-skills training.

Primary Outcome Measures

Name	Time	Method
Neuropsychological test battery, including measures of visual, verbal memory, and problem-solving abilities	Measured pre- and post-treatment
Schizophrenia symptoms	Measured pre- and post-treament
UCSD Performance-Based Skills Assessment	Measured pre- and post-treatment

Trial Locations

Locations (1)

Schizophrenia Rehabilitation Program, Institutes of Living; 🇺🇸 Hartford, Connecticut, United States