Pharmacists Intervention to Improve Hypertension Management in Primary Care
- Conditions
- Hypertension
- Interventions
- Behavioral: Referral of hypertensive patients to the attending physician
- Registration Number
- NCT03274531
- Lead Sponsor
- Wilhelminenspital Vienna
- Brief Summary
Arterial hypertension is the single largest contributor to mortality world-wide, and only 30-50% of diagnosed and treated patients achieve their blood pressure goal. The APOTHECARE trial is designed to identify treated patients with uncontrolled hypertension in community pharmacies in order to improve blood pressure control through intensification of antihypertensive therapy.
- Detailed Description
Patients with medically treated arterial hypertension, who attend a pharmacy in order to obtain their antihypertensive medication are invited to participate in the trial.
The main inclusion criteria is uncontrolled hypertension, as determined by an automated office blood pressure measurement at a threshold of 135/85 mmHg.
Main exclusion criteria include a first-ever prescription of an antihypertensive agent, resistant hypertension, systolic blood pressure ≥ 180 mmHg and dialysis.
Randomization occurs on the level of pharmacies (cluster randomization).
Patients in the interventional arm are immediately referred to their treating physician for up-titration of antihypertensive therapy. Re-examination of automated automated office blood-pressure occurs in the respective pharmacy, and patients are referred to their treating physician again if required. These measures are accompanied by a structured and educational blood pressure record card.
Patients in the observational arm undergo periodic automated office blood pressure measurements and are referred to their treating physician at the end of the trial in case of persistently uncontrolled blood pressure.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 497
- Written informed consent
- Age > 18 years
- Medically pre-treated arterial hypertension
- Automated office blood pressure ≥ 135 mmHg systolic or ≥ 85 mmHg diastolic
- First ever prescription of antihypertensive medication
- First prescription of a new antihypertensive substance or dose adjustment
- Prior therapy with 4 or more different antihypertensive substances
- Systolic blood pressure ≥ 180 mmHg
- Dialysis
- Adherence to the study protocol not to be anticipated
- Inclusion into the study at another study site
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Interventional Arm Referral of hypertensive patients to the attending physician Immediate referral of hypertensive patients to the attending physician based on automated office blood pressure measurements
- Primary Outcome Measures
Name Time Method Proportion of patients with systolic blood pressure <135 mmHg and diastolic blood pressure < 85 mmHg at 10 weeks of follow-up (automated office blood pressure measurement) 10 weeks Primary endpoint
- Secondary Outcome Measures
Name Time Method Proportion of patients with systolic blood pressure <135 mmHg and diastolic blood pressure < 85 mmHg (automated office blood pressure measurement) 20 weeks Secondary endpoint
Proportion of patients with systolic blood pressure <135 mmHg and diastolic blood pressure < 85 mmHg (home blood pressure, mean of available readings) 20 weeks Secondary endpoint, patients with available home blood pressure measurements
Change in average systolic blood pressure (automated office blood pressure measurement) 20 weeks Secondary endpoint
Trial Locations
- Locations (52)
Apotheke Bad Erlach
🇦🇹Bad Erlach, Austria
Buchen-Apotheke
🇦🇹Alland, Austria
Kur-Apotheke
🇦🇹Bad Vöslau, Austria
Oetscherland-Apotheke
🇦🇹Gaming, Austria
Landschafts-Apotheke
🇦🇹Baden, Austria
Apotheke Am Goettweiger
🇦🇹Furth, Austria
Apotheke Gmuend Neustadt
🇦🇹Gmünd, Austria
Apotheke zum heiligen Georg
🇦🇹Gaweinstal, Austria
Apotheke Zum Auge Gottes
🇦🇹Gmünd, Austria
Marien-Apotheke
🇦🇹Gramatneusiedl, Austria
Stadt-Apotheke
🇦🇹Schrems, Austria
Apotheke Zu Maria Trost
🇦🇹Kirchberg am Wagram, Austria
Kreis-Apotheke Zum schwarzen Adler
🇦🇹Korneuburg, Austria
Die Blaue Apotheke
🇦🇹Klosterneuburg, Austria
Adler-Apotheke
🇦🇹Langenlois, Austria
Kamptal-Apotheke
🇦🇹Langenlois, Austria
Apotheke Zur Madonna
🇦🇹Neunkirchen, Austria
Merkur-Apotheke
🇦🇹Neunkirchen, Austria
Triesting-Apotheke,
🇦🇹Oberwaltersdorf, Austria
Apotheke Zum St. Nikolaus
🇦🇹Pottendorf, Austria
Apotheke Zum heiligen Georg
🇦🇹Pitten, Austria
Apotheke Purgstall
🇦🇹Purgstall, Austria
Apotheke Zur Mariahilf
🇦🇹Wiener Neustadt, Austria
Hippolyt-Apotheke
🇦🇹Sankt Poelten, Austria
Johannes-Apotheke
🇦🇹Traisen, Austria
Urania Apotheke
🇦🇹Vienna, Austria
Activ Apotheke Tribuswinkel
🇦🇹Tribuswinkel, Austria
Siebenbrunnen Apotheke
🇦🇹Vienna, Austria
Heilfried Apotheke
🇦🇹Vienna, Austria
Ludwigs Apotheke
🇦🇹Vienna, Austria
Friedrichs Apotheke
🇦🇹Vienna, Austria
Adler Apotheke
🇦🇹Vienna, Austria
Linden Apotheke
🇦🇹Vienna, Austria
Apotheke Neu Kagran
🇦🇹Vienna, Austria
St. Hubertus Apotheke
🇦🇹Vienna, Austria
Rosen Apotheke
🇦🇹Vienna, Austria
Bahnhof-Apotheke
🇦🇹Wiener Neustadt, Austria
Zehnerguertel-Apotheke
🇦🇹Wiener Neustadt, Austria
Apotheke Wimpassing
🇦🇹Wimpassing, Austria
Kuenringer Apotheke
🇦🇹Zwettl Stadt, Austria
Center Apotheke
🇦🇹Sankt Poelten, Austria
Apotheke Zur heiligen Dreifaltigkeit
🇦🇹Wolkersdorf, Austria
Arkaden Apotheke
🇦🇹Vienna, Austria
St. Georgs-Apotheke
🇦🇹Himberg, Austria
Wallhof-Apotheke
🇦🇹Rannersdorf, Austria
Apotheke Zum schwarzen Adler
🇦🇹Zwettl Stadt, Austria
Kronen-Apotheke
🇦🇹Lilienfeld, Austria
Apotheke Zur Mutter Gottes
🇦🇹Traismauer, Austria
Birken Apotheke
🇦🇹Vienna, Austria
Apotheke Sued
🇦🇹Sankt Poelten, Austria
Rosen-Apotheke
🇦🇹Sankt Pölten, Austria
Linden-Apotheke
🇦🇹Seitenstetten Markt, Austria