The effect of Metoclopramide on Aspiration and Pneumonia in Stroke patients fed via nasogastric tubes

Keele University (UK)0 个研究点目标入组 60 人开始时间: 2014年6月3日最近更新: 2015年1月13日

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•All adult patients admitted to the Acute Stroke Unit at University Hospital of North Staffordshire were considered for enrolment into the study if they required placement of a nasogastric tube for enteral feeding and if they could be recruited either before or within 48 hours of insertion of the nasogastric tube, no longer than a week had passed since the stroke.

•1. Patients who had a nasogastric tube in place for more than two days
•2. More than seven days following the stroke
•3. Patients with signs and symptoms of a chest infection before recruitment
•4. Patients with a known oesophageal stricture or a carcinoma which would interfere with the insertion of a nasogastric tube
•5. Patients with terminal illnesses such as advanced malignancies
•6. Patients on concurrent dopaminergic drugs
•7. Patients with a history of neurodegenerative condition which should affect swallowing e.g. Parkinson?s disease and motor neurone disease
•8. Patients who had presented as strokes, but later were diagnosed to have a non stroke pathology (e.g. brain tumour) were excluded retrospectively
•9. Pregnancy
•10. Patients recruited to another study
•11. Patients where a decision not to treat actively had been made either due to poor chances of survival due to severity of the stroke or because of the patient?s prior expressed wishes
•12. Known contraindications for the use of metoclopramide: Gastro-intestinal obstruction, perforation or haemorrhage; 3-4 days after gastro-intestinal surgery; phaeochromocytoma; breast-feeding

发起方

Keele University (UK)