MPI Predicts Outcome of CRC Elderly Patients (MPI=MULTIDIMENSIONAL PROGNOSTIC INDEX; CRC=COLORECTAL CANCER)

Completed

• Conditions: Fragility; Elderly; Colorectal Cancer

• Registration Number: NCT04594655
• Lead Sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Brief Summary

Patients aged ≥75 year scheduled for CRC surgery were studied (104 cases) and variables associated with major postoperative complications / mortality were evaluated. The importance of this report is that MPI-score resulted strongly associated with major complications and it was a primary component of an individual prediction model.

Detailed Description

Patients aged ≥75 year scheduled for CRC surgery were studied (104 cases) and variables associated with major postoperative complications / mortality were evaluated. The MPI (multidimensional prognostic index)-score resulted strongly associated with major complications. also, it was a primary component of an individual prediction model (LASSO model).

Study Timeline

• Study Start: 2017-10-01
• Primary Completion: 2019-08-31
• Study Completion: 2019-09-30
• Status Verified: 2020-10
• Study First Submitted: 2020-10-11
• Study First Submitted QC: 2020-10-17
• Last Update Submitted: 2020-10-17
• Study First Posted: 2020-10-20
• Last Update Posted: 2020-10-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

All CRC patients aged ≥75 years, who were scheduled for elective surgery and able to express their consent to treatment, were considered.

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Exclusion Criteria

emergency surgery; patients aged <75 years; patients unable to sign informed consent.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MPI and major morbidity	30 days	The primary goal of the FRAGIS (Frailty Assessment by Geriatric Investigation in Surgery) study was to evaluate the association between the MPI score and the occurrence of major postoperative complications within 30 days of CRC surgery.

Secondary Outcome Measures

Name	Time	Method
Prediction of complication	90 days	The secondary goal was to develop a model to predict the individual risk of postoperative complications, allowing the appropriate patient selection for surgery.

Trial Locations

Locations (1)

ASST Spedali Civili; 🇮🇹 Brescia, Lombardia, Italy