Appendicoliths in Acute Complicated Appendicitis Patients With Abscess

Not yet recruiting

• Conditions: Acute Complicated Appendicitis With Abscess

• Registration Number: NCT06469086
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

Complicated appendicitis, characterized by the presence of an abscess or perforation, involves acute inflammation of the peritoneum secondary to an infection of the appendix, presenting additional challenges for management. Traditionally, the standard treatment for complicated appendicitis has been surgical intervention. However, conservative management, involving antibiotics and drainage, has emerged as a viable alternative for selected patients. Recent studies emphasize the importance of selecting appropriate antibiotics based on local resistance patterns and the patient's clinical condition. Broad-spectrum antibiotics, including those targeting anaerobic bacteria, are often preferred. In addition, advances in imaging technology, such as ultrasound-guided drainage, have improved the precision and success rates of percutaneous abscess drainage. This minimally invasive approach helps manage localized infections and can prevent the need for immediate surgery.

One factor that has gained significant attention in determining the success of conservative treatment for acute complicated appendicitis is the presence of appendicoliths-calcified deposits within the appendix. This study aims to investigate the clinical significance of appendicoliths in the conservative management of acute complicated appendicitis with abscesses.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-16
• Study First Submitted QC: 2024-06-16
• Last Update Submitted: 2024-06-20
• Study First Posted: 2024-06-21
• Last Update Posted: 2024-06-24
• Study Start: 2025-01-01
• Primary Completion: 2025-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients who aged ≥18 years, who diagnosed as acute appendicitis clinically, who had peri-appendiceal abscess larger than 2 cm in diameter on CT scan, who agreed conservative treatment first, who refused immediate emergency surgery

Exclusion Criteria

• Patients younger than 18 years, those with malignancies, those with incomplete clinical or pathological records were excluded from the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The success rate of conservative treatment	January 01, 2025 to December 31, 2025.

Secondary Outcome Measures

Name	Time	Method
Postoperative complications	January 01, 2025 to December 31, 2025.
Length of postoperative hospital stay	January 01, 2025 to December 31, 2025.
The surgical approach used	January 01, 2025 to December 31, 2025.