NL-OMON24946招募中不适用
Identifying the underlying mechanisms and consequences of the loss of nasal T cells in vital and frail older individuals
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- MC
- 入组人数
- 170
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Healthy elderly (>65yrs) that are not frail (frailty score 1-3)
- •Frailty (frailty score =4) elderly (>65yrs) These will be consist of individuals without a history of recurrent respiratory infections or with >2 self-reported episodes of respiratory infection in the past year.
- •Healthy young (18-35yrs) adults
排除标准
- •Incompetence to provide informed consent prior or during study
- •Current smoker or >40 pack year history
- •History of severe nose bleedings
- •Diagnosed with asthma, COPD or chronic rhinosinusitis
- •Use of inhalation corticosteroids or antibiotics in the past 6 weeks
- •Current use of anti-coagulants (to prevent nosebleeds)
- •Respiratory tract infection or common cold in the past 2 weeks
- •Immunocompromised individuals (with primary immune deficiency or secondary immune deficiency)
- •Life expectancy <28 days in the opinion of study physician
- •Vaccination in the 2 months prior to study start
- •A potential subject that is only excluded from participation based on a recent vaccination will be asked to re-participate 2 months post vaccination.
研究者
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