Comparison Effects of Negative Calorie Diet and Low-calorie Diet on Weight Loss and Lipid Profile in Sedentary Overweight/Obese Middle-aged and Older Women
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 37
- Primary Endpoint
- Weight
Study Overview
Brief Summary
Negative-calorie diet is among the popular dieting guides for weight loss; however, there is still little knowledge about this method. The present study aimed to determine the effects of negative-calorie diet on weight loss and lipid profile, and to compare its efficiency with low-calorie diet.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 45 Years to 75 Years (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Non-smokers and weight-stable (± 2 kg, for more than one year) with no history of regular exercise in at least three months before the study.
Exclusion Criteria
- •History of CVD and other disorders such as diabetes, depression, eating disorders, chronic medications, kidney disease, cancer, food allergies or intolerances to items used in meals.
- •Subjects with abnormality in thyroid or Electrocardiograph, any history of anti-obesity medication or weight loss drugs or dietary supplementations for weight control.
Arms & Interventions
Study group I
Study group I (19 participants) received the NCD (details of diet: 15% protein, 75% carbohydrates, 10% fat). Both groups had 15% caloric restriction from their maintenance energy requirements.
Intervention: NCD (Dietary Supplement)
Study group II
Study group II (18 participants) received the LCD or healthy weight maintenance diet (details of diet: 15% protein, 55% carbohydrates, 30% fat).Both groups had 15% caloric restriction from their maintenance energy requirements.
Intervention: LCD (Dietary Supplement)
Outcomes
Primary Outcomes
Weight
Time Frame: pre-study
assessed in kg
Total cholesterol (Total-C)
Time Frame: pre-study
assessed in mg/dl
High-density lipoprotein -cholesterol (HDL-C)
Time Frame: pre-study
assessed in mg/dl
Low-density lipoprotein -cholesterol (LDL-C)
Time Frame: pre-study
assessed in mg/dl
Triglycerides (TG)
Time Frame: pre-study
assessed in mg/dl
Secondary Outcomes
- Total cholesterol (Total-C)(3-month)
- Weight(3-month)
- High-density lipoprotein -cholesterol (HDL-C)(3-month)
- Low-density lipoprotein -cholesterol (LDL-C)(3-month)
Investigators
Mohammadreza Rezaeipour, MD, PhD
Assistant professor of sports medicine (sports injury and corrective movement)
University of Sistan and Baluchestan