Health Effects of Indoor Air Filtration in Healthy Chinese Adults: An Intervention Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Changes of Serum Cortisol Levels
研究概览
简要总结
This study aims to detect serum metabolite changes, as well as other health indicators with the intervention of air purifiers on a randomized, crossover, double-blind trial.
详细描述
The investigators conducted a randomized double-blind crossover trial among 60 healthy college students in Shanghai, China from November to December, 2015. These students lived in dormitories that were randomized into two groups and alternated the use of true or sham air purifiers for 9 consecutive days with a 2-week wash-out interval. All participants and research staffs were blinded to the group assignment. All participants were required to stay in their dormitory with the windows/doors closed for at least 50% of the time on weekdays and for 80% on weekends throughout the 9-day intervention period. All interventions started at 7 a.m. to avoid issues related to diurnal variation. Health endpoints, including blood pressure, fractional exhaled nitric oxide were evaluated and biological samples such as morning urine, fast blood and buccal cells were collected at baseline and immediately after the completion of each intervention period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy university students in Jiangwan Campus, Fudan university
- •Non-smoking, no history of alcohol or drug abuse
- •Free of chronic cardiovascular, respiratory, liver and kidney disease
- •Spend at least 50% (weekdays) or 80% (weekends) of time indoors
排除标准
- •Current or ever smokers
- •History of asthma, chronic bronchitis，cough, hypertension or other chronic inflammatory disease
- •acute infections
- •medication use in recent one month
结局指标
主要结局
Changes of Serum Cortisol Levels
时间窗: at the end of each 9-day intervention period
Using metabolomic methods to screen and quantify all the serum metabolites, and calculate changes in main metabolites in sham purification compared to real purification. Relative intensity was calculated by dividing the peak intensity of cortisol with the peak intensity of internal standard (2-chloro-D-phenylalanine methanol solution, 0.014mg/mL)
Changes of Serum Cortisone Concentration
时间窗: at the end of each 9-day intervention period
Use metabolomic methods to screen and quantify all the serum metabolites, and calculate changes in main metabolites in sham purification compared to real purification. Relative intensity was calculated by dividing the peak intensity of cortisone with the peak intensity of internal standard (2-chloro-D-phenylalanine methanol solution, 0.014mg/mL)
Changes of Serum Epinephrine Concentrations
时间窗: at the end of each 9-day intervention
Use metabolomic methods to screen and quantify all the serum metabolites, and calculate changes in main metabolites in sham purification compared to real purification. Relative intensity was calculated by dividing the peak intensity of epinephrine with the peak intensity of internal standard (2-chloro-D-phenylalanine methanol solution, 0.014mg/mL)
Changes of Serum Norepinephrine Concentration
时间窗: at the end of each 9-day intervention
Use metabolomic methods to screen and quantify all the serum metabolites, and calculate changes in main metabolites in sham purification compared to real purification. Relative intensity was calculated by dividing the peak intensity of cortisol with the peak intensity of internal standard (2-chloro-D-phenylalanine methanol solution, 0.014mg/mL)
次要结局
- Diastolic Blood Pressure(at the end of each 9-day intervention)
- Systolic Blood Pressure(at the end of each 9-day intervention period)
- Pulse Pressure(at the end of each 9-day intervention)