Ayuevedic management of thin endometrium

Phase 3

Not yet recruiting

• Conditions: Female infertility of uterine origin. Ayurveda Condition: VANDHYA,

• Registration Number: CTRI/2025/03/082464
• Lead Sponsor: Institute of Teaching and Research in Ayurveda

Brief Summary

Vandhyatva (Infertility) has been recognized since the Vedic period. Acharya Sushruta has included Vandhya in

Yonivyapadas and Artavavaha Strotasa Viddha Lakshanas. He has described four essential factors for fertility. Ritu

(fertile period), Kshetra (well primed, disease-free endometrial bed), Ambu (sufficient unobstructed blood circulation)

and Beeja (quality spermatozoa from unvitiated, healthy male and quality ovum from disease free, healthy female)

are essential factor for conception. In which uterine factors endometrial abnormalities play a major role in the

causation of infertility. Endometrium forms by the part of Prasada Rasa and Rakta Dhatu and Sthanika Agni. Ruksha

Guna of Vata and Ushna - Tikshna Guna of Pitta are the two main etiological factors affecting endometrium.

Rationality For the Selection of The Topic:

Endometrium plays a major role in establishing a pregnancy and any alteration in this, could be a potential cause for

failure of implantation thus affecting fertility. Extended oestrogen treatment and adjuvant therapy, such as low dose

aspirin, vaginal Sildenafil, etc. are used in modern science for improving endometrium thickness. Still, there isn’t any

proven incidence of this treatment. Other treatments like In-Vitro Fertilization (IVF) - Embryo Transfer (ET), Gamete

Intra Fallopian Transfer (GIFT), etc. are also available. But all these treatments require a healthy endometrium.So this

topic is selected.

Aims and Objective:

To evaluate the efficacy of Ardhamatrika Yogabasti, Shatapushpadi Taila Uttarabasti and Tila Kwatha orally in the

management of Vandhatyva (female infertility) w.s.r. to thin endometrium.

Materials And Methods:

20 patients should fulfill the inclusion criteria for thin endometrium and will be selected in the clinical study.

Follow-up:

Patients will be advised to visit the hospital every 2 weeks during the treatment and for 1 month after the treatment as

a follow-up. Side Effects:

These drugs have no known unwanted effects. It is possible that it may also cause some problems that we are not

aware of. Adverse Drug Reaction if any observed will be reported to the Pharmacovigilance cell of I.T.R.A.,

Jamnagar.

Results: The efficacy of the therapy will be assessed on the basis of subjective and objective criteria.

Benefits: Project will help us to resolve the research question. Collected information from this research project will

be kept confidential, all outcomes will be noted in tabular form and appropriate statistical tests will be applied to

compare the effect.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-03-30
• Last Update Posted: 2025-06-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

Female patients having primary or secondary infertility with endometrial thickness less than equal to 7mm diagnosed by TVS with ovulatory cycle and anovulatory cycle, Female patients fit for Basti and Uttarabasti.

Exclusion Criteria

• Female patients having infertility due to bilateral tubal blockage, hydro or pyosalpinx, Carcinoma of reproductive tract, Active inflammatory disease, e.g. Acute PID, positive case of HIV, VDRL, HBsAg and HCV, Abnormal uterine anatomy, endometrial tuberculosis, myoma, endometriosis, Patients with history of cardiac diseases, chronic liver disease, uncontrolled hypertension (Systolic BP above 160 & Diastolic above 100 mmHg), uncontrolled diabetes mellitus (above the range of 160 mg/dl.
• RBS), Female patients contraindicated for Basti and Uttarabasti.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected to increase endometrial thickness	12 weeks

Secondary Outcome Measures

Name	Time	Method
To correct menstrual irregularities like dysmenorrhoea and scanty menses, To increase the blood flow of uterus by colour doppler study	10 weeks

Trial Locations

Locations (1)

Institute of Teaching and Research in Ayurveda; 🇮🇳 Jamnagar, GUJARAT, India

Institute of Teaching and Research in Ayurveda

🇮🇳Jamnagar, GUJARAT, India

Dr Rinkalben Kantibhai Bumtariya

Principal investigator

7486855126

rinkalkantibhai@gmail.com