Effectiveness of Quadratus Lumborum Block After Nephrectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 105
- 试验地点
- 2
- 主要终点
- Total consumption of oxycodone
研究概览
简要总结
Oxycodone consumption and postoperative pain intensity in patients undergoing nephrectomy procedures. Of all study participants, 50% will obtain quadratus lumborum block (QLB).
详细描述
Patients undergoing nephrectomy procedures will be allocated to one of the study arms. At the end of an operation, still under general anesthesia, 50% patients will obtain QLB with ropivacaine.
Ultrasound-guided QLB will be performed on the side of surgery with 0.375% ropivacaine solution (0.2 mL per kg).
Every patient will get patient-controlled analgesia pump with oxycodone in the postoperative period.
Postoperative pain will be measured with VAS (visual-analogue scale) 2, 4, 8, 12 and 24 hours after the end of the operation. 24 -hours period.
At the 1, 3, 6 months patients will be interviewed by phone to assess neuropathic pain. Neuropathic Pain Symptom Inventory (NPSI) will be used.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
A regional block will be performed under general anesthesia. Patients will not be aware of this procedure.
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •obtained consent
- •nephrectomy procedure
排除标准
- •coagulopathy allergy to local anesthetics depression, antidepressant drugs treatment epilepsy usage of painkiller before surgery addiction to alcohol or recreational drugs
研究组 & 干预措施
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: Rocuronium (Drug)
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: QLB (Procedure)
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: PCA (Device)
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: GA (Procedure)
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: Oxycodone (Drug)
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: Sevoflurane (Drug)
QLB
At the end of surgery, QLB with ropivacaine will be done on the side of the operation.
干预措施: Fentanyl (Drug)
Control
Standard care. No regional blocks.
干预措施: PCA (Device)
Control
Standard care. No regional blocks.
干预措施: GA (Procedure)
Control
Standard care. No regional blocks.
干预措施: Oxycodone (Drug)
Control
Standard care. No regional blocks.
干预措施: Sevoflurane (Drug)
Control
Standard care. No regional blocks.
干预措施: Fentanyl (Drug)
Control
Standard care. No regional blocks.
干预措施: Rocuronium (Drug)
结局指标
主要结局
Total consumption of oxycodone
时间窗: 24 hours after the end of surgery.
Overall use of oxycodone administered by PCA pump will be assessed.
次要结局
- Pain intensity(24 hours after the end of surgery)
- Chronic pain(6 months after the surgery)
研究者
Michał Borys
M.D., Ph.D.
Medical University of Lublin