The Primary Objective of This Study Was to Investigate the Effect of Insulin on Myocardial Perfusion in Patients Undergoing Cardiac Surgery for CPB Using Transesophageal Echocardiography (TEE) to Detect CSBF and the Secondary Objective Was to Observe the Effect of Insulin on Cardiac Function and Markers of Myocardial Injury
Overview
- Phase
- Not Applicable
- Intervention
- Glucose insulin potassium
- Conditions
- Insulin
- Sponsor
- Yangzhou University
- Enrollment
- 74
- Locations
- 1
- Primary Endpoint
- Changes in the coronary sinus blood flow spectrum
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The primary objective of this clinical trial was to investigate the effects of insulin on myocardial blood flow reflected by CSBF which was evaluated by TEE. The second aim was to observe the effect of insulin on cardiac function and markers of myocardial damage.
Investigators
Zhuan Zhang
Principal Investigator
Yangzhou University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Glucose-insulin-potassium
Intervention: Glucose insulin potassium
Outcomes
Primary Outcomes
Changes in the coronary sinus blood flow spectrum
Time Frame: from 30 minutes after intubation to 1 hour after intubation , from 30minutes before the end of the surgery to the end of the surgery
coronary sinus blood flow spectrum changes such as SVTI、DVTI、AVTI are assessed by TEE
Changes in left ventricular diastolic function
Time Frame: from 30 minutes after intubation to 1 hour after intubation , from 30minutes before the end of the surgery to the end of the surgery
Changes in left ventricular diastolic function are assessed by TEE, such as changes in pulmonary venous blood flow
Secondary Outcomes
- Changes in the level of SVR(into ICU 30 minutes)
- Changes in the level of Cardiac output(into ICU 30 minutes)
- Changes in the level of Systolic Blood Pressure/Diastolic Blood Pressure(Mean Arterial Pressure)(into ICU 30 minutes)
- Changes in the level of SVRI(into ICU 30 minutes)
- Changes in the level of Heart Rate(into ICU 30 minutes)
- Changes in the level of Cardiac index(into ICU 30 minutes)