The Primary Objective of This Study Was to Investigate the Effect of Insulin on Myocardial Perfusion in Patients Undergoing Cardiac Surgery for CPB Using Transesophageal Echocardiography (TEE) to Detect CSBF and the Secondary Objective Was to Observe the Effect of Insulin on Cardiac Function and Markers of Myocardial Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Changes in the coronary sinus blood flow spectrum
研究概览
简要总结
The primary objective of this clinical trial was to investigate the effects of insulin on myocardial blood flow reflected by CSBF which was evaluated by TEE. The second aim was to observe the effect of insulin on cardiac function and markers of myocardial damage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Glucose-insulin-potassium
干预措施: Glucose insulin potassium (Drug)
结局指标
主要结局
Changes in the coronary sinus blood flow spectrum
时间窗: from 30 minutes after intubation to 1 hour after intubation , from 30minutes before the end of the surgery to the end of the surgery
coronary sinus blood flow spectrum changes such as SVTI、DVTI、AVTI are assessed by TEE
Changes in left ventricular diastolic function
时间窗: from 30 minutes after intubation to 1 hour after intubation , from 30minutes before the end of the surgery to the end of the surgery
Changes in left ventricular diastolic function are assessed by TEE, such as changes in pulmonary venous blood flow
次要结局
- Changes in the level of SVR(into ICU 30 minutes)
- Changes in the level of Cardiac output(into ICU 30 minutes)
- Changes in the level of Systolic Blood Pressure/Diastolic Blood Pressure(Mean Arterial Pressure)(into ICU 30 minutes)
- Changes in the level of SVRI(into ICU 30 minutes)
- Changes in the level of Heart Rate(into ICU 30 minutes)
- Changes in the level of Cardiac index(into ICU 30 minutes)
研究者
Zhuan Zhang
Principal Investigator
Yangzhou University