Comparison of 30% nitrous oxide with therapeutic dose nimodipine on cerebral and systemic vascular physiology - Nitrous Oxide compared with nimodipine
- Conditions
- This is part of a series of studies investigating the potential therapeutic use of low dose nitrous oxide in the treatment of cerebral vasospasm, a condition which occurs following brain injury and stroke. The aim is to compare the effects of 30% nitrous oxide with therapeutic dose of nimodipine (the current treatment for cerebral vasospasm) on cerebral vascular physiology and systemic vascular effects.
- Registration Number
- EUCTR2010-022874-15-GB
- Lead Sponsor
- niversity of Nottingham
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 20
Males and Females aged between 18 and 50
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
People with history or evidence of cardiac or vascular disease.
Systemic illness.
Known hypersensitivity to nimodipine
People with evidence of a neurological disorder
People with liver disease
Smokers
Pregnant or lactating females
Pneumothorax or emphysema.
People having received recent intraocular injection of gas (such as SF6).
Middle ear conditions.
People on the following prescription medication: Antihypertensives, Antiepileptics, Rifampicin, Macrolide antibiotics, Anti-HIV medication, Azole antimycotics, Antidepressants, Cimetidine.
Volunteers who are found to have evidence of carotid artery disease by Duplex scan screening will not take part in the study.
In females pregnancy will be excluded by an hCG test within 24 hours preceding MRI scan.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method