TCTR20170130003CompletedPhase 4
Genicular nerve bipolar radiofrequency ablation for chronic osteoarthritis knee pain: A double-blind randomized controlled trial
/A0 sites64 target enrollmentStarted: January 30, 2017Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Enrollment
- 64
Study Overview
Brief Summary
We found that a substantial proportion of individuals experienced meaningful pain relief with RFA or sham RFA coupled with local anesthetic and steroid injections, with no statistically significant or clinically important differences between groups. In conjunction with recent evidence suggesting that ablating 3 nerves may not be sufficient to treat knee OA and that targeting more than 3 nerves provides better outcomes.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 Years to 85 Years (—)
- Sex
- All
Inclusion Criteria
- •1.Age 18 - 85 years and persistent knee pain > 6 months
- •2.Diagnosis of radiologically verified Kellgren-Lawrence grade III or IV osteoarthritis
- •3.No response to conservative treatment
- •4.Positive response to diagnostic geniculate nerve block
Exclusion Criteria
- •1.Acute knee pain with inflammation
- •2.Taking anticoagulant
- •3.History of knee surgery
- •4.Serious psychiatric/neurological problems
- •5.Known radiculopathy
- •6.Intraarticular injection during previous 3 months : steroids, hyaluronic acid
- •7.Previous RF treatment
- •8.Connective tissue disease affecting knee
Investigators
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