Comparison of the Effects of Neostigmine With Sugammadex on Postoperative Nausea and Vomiting.

Phase 4

Completed

• Conditions: Incidence of Postoperative Nausea and Vomiting
• Interventions: Drug: Neostigmine; Drug: sugammadex

• Registration Number: NCT02286752
• Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Brief Summary

Postoperative nausea and vomiting is one of most common complications after general anesthesia. Female sex, history of postoperative nausea and vomiting, motion sickness, non smoker status, opioid administration are known as risk factors for developing postoperative nausea and vomiting.

It has been suggest that antagonism of residual neuromuscular block with a mixture of neostigmine and atropine at the end of the surgery increases the risk of postoperative nausea and vomiting.

Sugammadex is a very safe drug with almost no serious adverse effects. The known adverse effects include slight coughing, movement, an altered taste sensation in the mouth, transient prolongation of the QT interval, hypersensitivity, and a short term prolongation of the activated partial thromboplastin time.

The aim of this study was to compare the sugammadex versus neostigmine plus atropine for reversal of rocuronium induced neuromuscular blockade in terms of incidence of postoperative nausea and vomiting.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-11-03
• Study First Submitted QC: 2014-11-05
• Study First Posted: 2014-11-10
• Status Verified: 2015-01
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Last Update Submitted: 2015-01-11
• Last Update Posted: 2015-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status 1 and 2
• endotracheal intubation and general anesthesia scheduled for elective surgery

Exclusion Criteria

• age < 18 years, > 65 years
• pregnancy
• refusal to participate and patients already participating in another study
• allergy to study drugs
• communication difficulty
• psychiatric and neurological disorders
• use of analgesics or sedative or antiemetic drugs within 24 hours before surgery.
• emergency surgery
• history of drug or alcohol abuse
• ASA 3 and above
• patients with vertigo
• Laparoscopic surgery, oncologic surgery, strabismus and mid ear surgery neurosurgery, gynecologic surgery, breast surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
neostigmine	Neostigmine	-
sugammadex	sugammadex	-

Primary Outcome Measures

Name	Time	Method
Verbal Descriptive Scale	within postoperative 24 hours	0: no nausea 1: mild 2: moderate 3: severe

Trial Locations

Locations (1)

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital; 🇹🇷 Altınordu, Ordu, Turkey