NCT04821492已完成不适用
Evaluation of the Relationship Between Homocysteine Levels and Bone Mineral Density in Postmenopausal Women
Fundación Santiago Dexeus Font1 个研究点 分布在 1 个国家目标入组 760 人开始时间: 2019年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 760
- 试验地点
- 1
- 主要终点
- Total hip T-score
研究概览
简要总结
The association between Homocysteine (Hcy) levels and bone mineral density (BMD) has been debated. Some studies have found a relationship between increased Hcy plasma levels and BMD in contrast; other studies have not found a relationship. The purpose of our study was to investigate whether or not Hcy plasma levels are related to BMD in a group of postmenopausal women.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Postmenopausal women
- •BMD measured by dual-energy X-ray absorptiometry (DXA)
排除标准
- •Primary ovarian failure
- •Early menopause
- •Cardiovascular, liver, or renal diseases
- •Surgical menopause
- •History of cancer
- •Receiving treatment known to influence levels of Hcy or bone mineralization (folates or vitamin B12 supplements, menopausal hormonal treatment, corticosteroids, anticonvulsants, heparin, thiazide diuretics, and antiresorptive agents).
结局指标
主要结局
Total hip T-score
时间窗: one year before or after Homocysteine levels
Femoral neck T-score
时间窗: one year before or after Homocysteine levels
BMD expressed in absolute values as g/cm2
时间窗: one year before or after Homocysteine levels
Lumbar spine T-score
时间窗: one year before or after Homocysteine levels
次要结局
未报告次要终点
研究者
Pascual García
Principal Investigator
Institut Universitari Dexeus
研究点 (1)
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