Cerebral Small Vessel Disease Registry Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Overall outcomes in patients with cerebral small vessel disease.
研究概览
简要总结
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Small Vessel Disease (CSVD) and in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CSVD, , to find independent imaging markers, and to optimize clinical management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sign informed consent.
- •At least one of the following CSVD MRI characteristics: ①recent small subcortical infarct;②lacune of presumed vascular origin;③white matter hypertensity of presumed vascular origin;④perivascular space;⑤cerebral microbleeds;⑥brain atrophy
排除标准
- •Unable to cooperate with inspectors
- •Non-vascular white matter lesions
- •Other cognitive diseases (such as alzheimer's disease, Parkinson's disease or thyroid disease)
- •Serious systemic illness, such as heart, liver, kidney disease or major mental illness
- •Contraindications for imaging examination
结局指标
主要结局
Overall outcomes in patients with cerebral small vessel disease.
时间窗: From date of enrollment until the date of death from any cause, assessed up to 30 years
record the occurrence of stroke and use modified Rankin Scale (mRS) to measure the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability.
次要结局
- the development of the burden of microbleeds in MRI(From date of enrollment until the date of death from any cause, assessed up to 30 years)
- the development of enlarged perivascular space in MRI(From date of enrollment until the date of death from any cause, assessed up to 30 years)
- the development of lacunes in MRI(From date of enrollment until the date of death from any cause, assessed up to 30 years)
- the development of the burden of white matter hypertension in MRI(From date of enrollment until the date of death from any cause, assessed up to 30 years)
研究者
Bin Cai
Professor
First Affiliated Hospital of Fujian Medical University