Neural Changes in Stroke Patients During Challenging Walking Tasks.

Recruiting

• Conditions: Stroke

• Registration Number: NCT06764290
• Lead Sponsor: Nanjing Medical University

Brief Summary

For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered.

Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds.

Detailed Description

Stroke participants will wear a 32-lead electroencephalogram electrode cap (Zhentai Technology Company, Xi 'an, China), first walk on a flat ground for 60 seconds, rest for 2 minutes, then walk on the pedal for 60 seconds, rest again for 2 minutes, and walk for 60 seconds with eyes-covered.

Study Timeline

• Study Start: 2024-04-01
• Study First Submitted: 2024-04-10
• Status Verified: 2025-01
• Study First Submitted QC: 2025-01-01
• Last Update Submitted: 2025-01-01
• Study First Posted: 2025-01-08
• Last Update Posted: 2025-01-08
• Primary Completion: 2025-01-30
• Study Completion: 2025-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• First-time occurrence of stroke confirmed by computed tomography or magnetic resonance imagingClinical diagnosis of stroke
• Disease duration of more than 14 days， less than 1 year
• Able to walk independently but with a lingering abnormal gait

Exclusion Criteria

• Lesions accumulate in the brainstem
• Lesions accumulate in the cerebellum
• Impaired vision
• Severe cognitive impairment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Weight Phase Lag Index	The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds	The Weighted Phase Lag Index (WPLI) is a measure used to quantify phase synchronization in electrophysiological data.Continuously measure the connectivity of the coupling of neural oscillatory activity in the brain, while being statistically more powerful in detecting changes in signal phase synchronization.The WPLI ranges from 0 to 1, with 0 indicating no phase synchronization and 1 indicating complete phase synchronization.
Relative power	The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds	The electroencephalogram signal in the time domain is converted into the relevant information in the frequency domain, the frequency bands are divided, and the relative power results of each channel in each frequency band are derived. Among them, delta:1-4Hz, theta:4-8Hz, alpha:8-15Hz, beta:15-30Hz, gamma:30-45Hz.

Trial Locations

Locations (2)

Geriatric Hospital of Nanjing Medical University, 269 Qingmen Street; 🇨🇳 Nanjing, Jiangsu, China

Geriatric Hospital of Nanjing Medical University; 🇨🇳 Nanjing, Jiangsu, China