NCT01669005CompletedNot Applicable
Obtaining Early Diagnosis and Prognosis in Urgent Sepsis (OEDIPUS) Study
Centre Hospitalier Universitaire Vaudois0 sites84 target enrollmentStarted: November 2007Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 84
Study Overview
Brief Summary
Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed.
Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients aged ≥18 years
- •autologous or allogeneic hematopoietic stem cells transplantation or induction/consolidation chemotherapy performed
Exclusion Criteria
- •No blood samples were taken
Investigators
Andrej Trampuz
MD
Centre Hospitalier Universitaire Vaudois
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