The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies

Completed

• Conditions: Neutropenia

• Registration Number: NCT01669005
• Lead Sponsor: Centre Hospitalier Universitaire Vaudois

Brief Summary

Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed.

Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia

Detailed Description

Not available

Study Timeline

• Study Start: 2007-11
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2012-08
• Study First Submitted: 2012-08-16
• Study First Submitted QC: 2012-08-17
• Last Update Submitted: 2012-08-17
• Study First Posted: 2012-08-20
• Last Update Posted: 2012-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• patients aged ≥18 years
• autologous or allogeneic hematopoietic stem cells transplantation or induction/consolidation chemotherapy performed

Exclusion Criteria

• No blood samples were taken

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified