To study the effectiveness of the drug tibolone in post menopausal depressio
- Conditions
- Health Condition 1: F32- Major depressive disorder, singleepisode
- Registration Number
- CTRI/2021/01/030776
- Lead Sponsor
- Department of psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
•Females who have currently achieved natural menopause
•Physiologic menopause with amenorrhea for at least 1 year
•Able to give informed consent
•First-onset or relapse depression during menopause
•Patients of depression diagnosed acc to DSM 5 criteria
1.Patients with any history of thyroid dysfunction, active or past history of a venous thromboembolic event, breast pathology, undiagnosed vaginal bleeding or abnormal Pap smear results .
2.Patients with any significant unstable medical illness such as epilepsy and diabetes or known active cardiac, renal or liver disease; or the presence of illness causing immobilisation.
3.Patients with psychotic symptoms or past history of severe mental illness.
4.Use of any form of estrogen, progestin or androgen as hormonal therapy, or antiandrogen including Tibolone or use of phytoestrogen supplements as powder or tablet
5.Smoking cigarettes or other nicotine products
6.Illicit drug use
7.More than 3 standard drinks per day
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method